Objective To observe the effect of Feibi Decoction Ⅱ（肺痹汤二号） on oxidative damage of lung tissue in mice exposed to sulfur dioxide（SO

2

）.Methods A total of forty-eight ICR mice were randomly divided into blank group

model group

traditional Chinese medicine prevention group

and traditional Chinese medicine treatment group with 12 mice in each group.Except for the blank group

the other groups of mice were treated with SO

2

static inhalation for 21 days.The Chinese medicine treatment group began to administer Feibi Decoction Ⅱ（concentration1 g/ml） 10 ml/（kg·d） intragastrically for 14 days from 1 week after exposure.In the Chinese medicine prevention group

10 ml/（kg·d） of Feibi Decoction Ⅱ was intragastrically administered from 1 week before exposure

and 10 ml/（kg·d） of normal saline was intragastrically administered to the blank group and model group

and all the treated groups were intragastrically administered for 28 days.The contents of malondialdehyde（MDA） and glutathione（GSH） and the activities of glutathione peroxidase（GSH-Px）

superoxide dismutase（SOD） and catalase（CAT） in lung tissue of mice were detected

and the lung tissues were observed by pathological HE staining.Results The results of HE staining showed that the alveolar walls of the mice in the model group were continuously destroyed

bullae appeared

and a large number of inflammatory cells infiltrated in the alveolar walls.Compared with the model group

the degree of inflammatory cell infiltration in the lung tissue of the Chinese medicine treatment group and the Chinese medicine prevention group was reduced

and the reduction was more obvious in the Chinese medicine prevention group.Compared with the blank group

the MDA content in the lung tissue of the model group increased

while the GSH

GSH-Px

SOD

and CAT contents decreased（P

<

0.05 or P

<

0.01）;the MDA contents in the lung tissue of the Chinese medicine prevention group and the Chinese medicine treatment group were higher than that of the blank group

and the GSH and CAT contents were also lower than those of the blank group（P

<

0.01）.The GSH-Px and SOD contents were not significantly different from the blank group（P

>

0.05）.Conclusion Feibi DecoctionⅡ could reduce the oxidative damage of lung tissue in mice exposed to SO

2

which may be related to the promotion of the absorption of inflammatory exudate in lung tissue of mice exposed to SO

2

.