The theoretical connotation and scientific thoughts of Five-spirit-zang Theory were analyzed from theoretical concept and modern explanation of Five-spirit-zang Theory

so as to explore the modern psychology and molecular biological mechanism of Five-spirit-zang Theory; Based on the core thoughts of Five-spirit-zang Theory

the "five spirits

five zang organs and five ambitions"as the feedback axis of Five-spirit-zang Theory was put forward. The significance of the theory of Five-spirit-zang Theory on the construction of traditional Chinese medicine（ TCM） psychology

TCM psychosomatic medicine

and the guiding value of clinical diagnosis and treatment of mental disorders and psychosomatic diseases was explored.