Objective To observe the effects of Chinese medicine Mimenghua（ Flos Buddlejae） Iontophoresis on interleukin-6（ IL-6）

intercellular adhesion molecule-1（ ICAM-1） in tear of dry eye patients and its possible mechanism. Methods A total of 60 patients（ 120 eyes） with dry eye were randomly divided into observation group（ 30 patients

60 eyes） and control group（ 30 patients

60 eyes）. The observation group was treated by Chinese medicine Flos Buddlejae iontophoresis and sodium hyaluronate eye drops

and the control group was only treated by sodium hyaluronate eye drops

for totally 4 weeks. The dry eye symptoms questionnaire scores

Schirmer-Ⅰtest

break-up time（ BUT）

cornea staining scores and the expression of IL-6

ICAM-1 in tear were compared before treatment and 2 and4 weeks after treatment. The curative effects were evaluated after 4 weeks’ treatment. The recurrence of dry eye was observed after 3 months of follow-up. Results The total effective rate was 93. 33% and 80. 00% in observation group in the control group. The clinical efficacy in the observation group was more significant（ P < 0. 01）. After 2 weeks and 4 weeks treatment

dry eye symptoms questionnaire scores

Schirmer-Ⅰtest

BUT test

cornea staining scores and tear IL-6

ICAM-1 expression of two groups were significantly improved

and the observation group was better than the control group（ P < 0. 05 or P < 0. 01）. After 3 months’ follow-up

the recurrence rate of the observation group was 14. 81%

which was lower than 39. 2% in the control group（ P < 0. 05）. Conclusion Chinese medicine Flos Buddlejae covered ocular surface by iontophoresis can eliminate or alleviate symptoms of dry eye patient

and reduce recurrence rate

the possible mechanisim might be inhibiting the expression of inflammatory cytokines IL-6 and ICAM-1.