Objective To observe the clinical effects and safety of self-made Wenjing Tongluo Soaking and Washing Prescription（温经通络泡洗方） combined with western medicine in treating type 2 diabetic peripheral neuropathy. Methods A total of 60 patients were randomly divided into treatment group and control group

with 30 cases in each group. The treatment group was given basic treatment plus self-made Wenjing Tongluo Soaking and Washing Prescription

while the control group was given basic treatment plus warm water soaking and washing. The basic treatment included routine hypoglycemia

hypotension

lipid lowering

dietary regulation

exercise and oral administration of Mecobalamin tablets. The soaking and washing was given once in the morning and evening

20 to 30 min each time

for 20 days. The clinical efficacy

changes of traditional Chinese medicine（TCM） syndrome score

Toronto clinical scoring system（TCSS） and current perception threshold（CPT） of both groups

as well as the adverse reactions were observed. Results The total effective rate was 76. 67% in the treatment group

higher than46. 67% in the control group（P < 0. 05）. After treatment

the TCM syndrome scores

TCSS and the CPT values of bilateral median nerve

superficial temporal and deep sacral nerve of both groups were significantly lower than those before treatment（P < 0. 05）

and those in the treatment group after treatment was significantly lower than those in the control group（P < 0. 05）. There were no significant changes in blood routine

liver function

renal function and electrocardiogram after treatment in both groups. Conclusion The self-made Wenjing Tongluo Soaking and Washing Prescription combined with western medicine has a good clinical efficacy in the treatment of type 2 diabetic peripheral neuropathy

without adverse reactions.