Objective To explore the effects and possible mechanism of Xiaoyu Jiangzhi Capsule（消瘀降脂胶囊） in preventing hyperlipidemia. Methods A total of 40 male New Zealand rabbits were randomly divided into normal control group

model control group

atorvastatin group

Xiaoyu Jiangzhi Capsule group and combined drug group

with 8 rats in each group. The normal control group was fed with basic diet daily

and the other groups were fed with high fat diet. From the 2 nd week

the normal control group and the model control group were given 30 ml of normal saline daily

and the atorvastatin group was given 2 mg/（kg · d） atorvastatin tablets by gavage

and the Xiaoyu Jiangzhi Capsule group was intragastrically administered with 100 mg/（kg·d） Xiaoyu Jiangzhi Capsule. The combined administration group was given 2 mg/（kg·d） atorvastatin tablets and 100 mg/（kg·d） Xiaoyu Jiangzhi Capsules by gavage for 10 weeks. Blood lipids

serum low density lipoprotein receptor（LDL-R）

apolipoprotein B100（Apo-B100）

lipoprotein lipase（LPL）

proprotein convertase subtilisin/kexin type 9（PCSK9） content

liver content of 3-hydroxy-3-methylglutaryl coenzyme A reductase（HMGCR）

peroxisome proliferator-activated receptor γ（PPAR-γ）

sterol regulatory element binding protein 2（SREBP2）

microsomal triacylglycerol transfer protein（MTP） and Niemann-Pick C1-Like 1（NPC1 L1） were detected in each group of experimental rabbits. Results Compared with the normal control group

the rabbits in the model control group had elevated blood lipid levels

elevated serum PCSK9 and Apo-B100 levels

decreased LDL-R and LPL levels

and HMGCR

PPAR-γ

MTP in the liver tissue and NPC1 L1 in the small intestine were increased

while liver tissue SREBP2 content decreased（P < 0. 05 or P < 0. 01）. Compared with the model control group

the blood lipid levels of the rabbits in each administration group were decreased to different degrees

and the decrease was more significant in the combined drug group（P <0. 05 or P < 0. 01）. The serum

liver tissue and small intestine tissues of the rabbits in each drug group were improved. And the combined drug group was obviously improved（P < 0. 05 or P < 0. 01）. Conclusion Xiaoyu Jiangzhi Capsule can prevent hyperlipidemia by regulating the metabolism of lipid metabolism related enzymes

inhibiting cholesterol absorption in the small intestine and cholesterol synthesis in liver cells

and strengthening the hydrolysis of triglycerides in the blood.