Liver fibrosis

as the early reversible phase of liver disease

is increasingly concerned by scholars.Macrophage polarization refers to the response state produced by macrophages in response to microenvironmental stimulation.The polarization state is divided into M1 and M2 types

which play an antagonistic role in different stages of liver fibrosis.It has similar connotations to mutually opposing and constraining

transformation

self-harmony and balance in the yin and yang theory of traditional Chinese medicine.This paper attempted to explore the role of macrophage polarization in liver fibrosis from the yin and yang theory of traditional Chinese medicine

proposing that when the effect of M1 macrophages is too strong

it can be treated with nourishing yin and nourishing blood

softening the liver and clearing fire

and selecting Yiguan Decoction（一贯煎）;When the effect of M2 macrophage is too strong

it can be treated with regulating qi and warming the liver

and selecting Nuangan Decoction（暖肝煎）.