Objective To evaluate the clinical efficacy of Shugan Weian Granules（疏肝胃安颗粒） combined with esomeprazole and mosapride in the treatment of gastroesophageal reflux disease（GERD）.Methods Totally120 patients with GERD were randomly divided into a control group（60 cases） and a treatment group（60 cases）.The control group was given esomeprazole magnesium enteric-coated tablets 20 mg each time

twice a day

and mosapride 5 mg each time

3 times a day.On the basis of the control group

the treatment group was given Shugan Weian Granules additionally

one dose per day.The treatment course of both group was 8 successive weeks.Before and after treatment

reflux disease questionnaire scale（RDQ）

SF-36 quality of life scale

and 24-hour esophageal pH monitoring were observed respectively.After treatment

the curative effect of both groups was analyzed according to the changes of the electronic gastroscope grading score before and after treatment.Results After treatment

the symptom scores of acid reflux

reflux

heartburn and non-cardiogenic chest pain and the total score of RDQ were significantly decreased in both groups（P<0.01）

while total score of RDQ and scores of all symptoms in the treatment group showed more significant decrease than those in the control group（P<0.05 or P<0.01）.In SF-36 scale

all scores in the treatment group and scores except the emotional function and mental health in the control group were significantly increased than those before treatment（P<0.05）.And the treatment group showed better improvement in physiological function

body pain

general health

emotional function

and mental health compared with the control group（P<0.05 or P<0.01）.The number of reflux lasting ≥5 min

the longest reflux duration

time percentage of pH<4

De Meester scoring were significantly reduced in both groups（P<0.05 or P<0.01）.Additionally

the longest reflux duration and DeMeester scoring showed more significant decrease in the treatment group compared with the control group（P<0.05）.There was no significant difference in the total effective rate of the gastroscopic examination between the 2 groups（P > 0.05）

although the rate of the control group was 77.19%

and the treatment group85.71%.Conclusion Shugan Weian Granules combined with esomeprazole and mosapride could significantly improve the clinical symptoms and life quality of GRD patients.The clinical effect of combined treatment is superior to using western medicine treatment alone.