Objective To evaluate the clinical effects of Xuekeshu Extract（ 血可舒浸膏） in the treatment of malignant hematopathy with blood stasis syndrome and study on its antithrombotic pathway from the aspect of thrombosis mechanism. Methods A total of 44 patients with malignant hematopathy and blood stasis syndrome were divided into a treatment group and a control group according to random number table

with 22 cases in each group. The control group was treated with routine therapy

and the treatment group was treated with oral administration of Xuekeshu Extract on the basis of the control group

5 g per time

three times per day. The clinical efficacy was evaluated by comparing the scores of blood stasis syndrome before and after treatment. The thrombotic events were observed. The hemodynamic indexes

coagulation function indicators

thrombelastogram（ TEG） and thrombosis related indexes（ thrombomodulin（ TM）

plasma endothelin 1（ ET-1）

protein C（ PC）

tissue plasminogen activator（ t-PA）

tissue plasminogen activator inhibitor（ PAI）） were detected

and the safety was observed. Results After treatment

in comparison of the 2 groups:（ 1） the curative effect and scores of traditional Chinese medicine syndromes of the treatment group were significantly better than those of the control group（ P < 0. 05）.（ 2） The incidence of thrombosis

remission rate and new thrombosis rate were significantly improved

but there were no statistical difference（ P >0. 05）.（ 3） The hemodynamic indexes showed that the whole blood high and medium shear rate viscosity

the red blood cell aggregation index

the reduced viscosity（ low shear rate） and the K value of the ESR equation all decreased（ P < 0. 05）.（ 4） TEG showed coagulation reaction time（ R time） was prolonged and maximum amplitude（ MA） value was decreased（ P < 0. 05）.（ 5） There was no significant difference in TM

ET-1

PC

t-PA

PAI（ P > 0. 05）. However

compared with those before treatment

ET-1 decreased and PC increased（ P < 0. 05）.（ 6）There was no significant difference in coagulation term and platelet count（ P > 0. 05）. No obvious adverse events occurred. Conclusion Xuekeshu Extract can obviously improve the symptoms of blood stasis in malignant hematopathy

and has certain effects on the prevention and treatment of thromboembolism. Xuekeshu Extract can reduce blood viscosity

and plasma endothelin

improve protein C content. It may play a role of antithrombus through the pathway of blood flow and vascular endothelium.