1. 广州中医药大学第一临床医学院
2. 广州中医药大学第一附属医院
纸质出版:2019
移动端阅览
[1]黄远程,潘静琳,黄超原,蒋凯林,廖柳,朱朝阳,李培武,刘凤斌.慢性萎缩性胃炎癌前病变证型、证素演变规律文献研究[J].中医杂志,2019,60(20):1778-1783.
HUANG Yuancheng, PAN Jinglin, HUANG Chaoyuan, et al. Literature Study on Distribution Features of Traditional Chinese Medicine Syndromes and Syndrome Elements in the Precancerosis of Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2019, 60(20): 1778-1783.
[1]黄远程,潘静琳,黄超原,蒋凯林,廖柳,朱朝阳,李培武,刘凤斌.慢性萎缩性胃炎癌前病变证型、证素演变规律文献研究[J].中医杂志,2019,60(20):1778-1783. DOI: 10.13288/j.11-2166/r.2019.20.016.
HUANG Yuancheng, PAN Jinglin, HUANG Chaoyuan, et al. Literature Study on Distribution Features of Traditional Chinese Medicine Syndromes and Syndrome Elements in the Precancerosis of Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2019, 60(20): 1778-1783. DOI: 10.13288/j.11-2166/r.2019.20.016.
目的探索慢性萎缩性胃炎(CAG)癌前病变证型、证素的演变规律。方法全面检索国内公开发表的CAG及胃癌前病变相关的证型、证素研究文献
文献纳入时间为各数据库建库至2018年10月31日
依据纳入与排除标准筛选文献
将CAG癌变过程依据病理结果划分为CAG、CAG伴肠上皮化生(IM)
CAG伴上皮内瘤变(IN)三个阶段
采集各个阶段证型、证素信息并录入数据库
进行统计分析。结果共纳入33篇CAG证型、证素研究文献
共报道病例数9261例。在CAG癌变过程中
基本证型为脾胃气虚证、脾胃湿热证、胃阴亏虚证、肝胃不和证、瘀阻胃络证、脾胃阳虚证
且以上证型在CAG癌变的3个阶段中分布差异均有统计学意义(P <0. 05)。其中
脾胃气虚证、胃阴亏虚证、肝胃不和证多见于CAG阶段
脾胃湿热证多见于CAG伴IM阶段
瘀阻胃络证、脾胃阳虚证更多见于CAG伴IN阶段。基本病位类证素为胃、脾、肝。基本病性类证素为气虚、气滞、热、阴虚、湿、瘀血、阳虚。其中气虚、气滞证素贯穿疾病3个阶段
而热、阴虚、湿、瘀血、阳虚证素在CAG癌变3个阶段分布差异有统计学意义(P <0. 05)。其中
CAG阶段以阴虚证素多见
热、湿证素在CAG、CAG伴IM阶段更为多见
CAG伴IN阶段以瘀血、阳虚证素多见。结论 CAG癌前病变的证型、证素呈现"虚实夹杂、因虚至实、因实致虚"的演变规律。脾胃气虚证为核心证型
气虚、气滞证素贯穿疾病始终。疾病病位在胃
与肝、脾相关。
Objective To understand the distribution features of traditional Chinese medicine( TCM) syndromes and syndrome elements in the precancerosis of chronic atrophic gastritis( CAG). Methods By searching literatures on CAG and gastric precancerous lesions related syndromes and syndrome elements published in domestic database. The included literature was from the begining of the database built to October 31
2018. The literatures were screened according to including and exclusion criteria. The canceration process of CAG was divided into 3 phrases of CAG
CAG with intestinal metaplasia( IM) and CAG with intraepithelial neoplasi( IN). Syndromes and syndrome elements of these phrases were collected and recorded into the database and then this paper maperformed a statistical analysis. Results A total of 33 papers with syndromes and syndrome elements and 9261 reported cases were enrolled. It was found that the basic syndromes of the process of precancerosis of CAG were qi deficiency of the spleen and stomach
heat and dampness of the spleen and stomach
yin deficiency of the stomach
disharmony of the liver and the stomach
stasis obstructing the stomach and yang deficiency of the spleen and stomach
and the syndrome mentioned above had statistical significance in the 3 phrases of the precancerosis of CAG( P < 0. 05). Among them
qi deficiency of the spleen and stomach
yin deficiency of the stomach and disharmony of the liver and the stomach were common in the phrase of CAG. Heat and dampness of the spleen and stomach was common in the phrase of CAG with IM. Stasis obstructing the stomach and yang deficiency of the spleen and stomach were common in CAG with IN.The major syndrome elements of disease location were stomach
spleen and liver. The major nature of the disease of the syndrome elements were qi deficiency
qi stagnation
heat
yin deficiency
dampness
static blood and yang deficiency. Among them
syndrome elements of qi deficiency and qi stagnation could be seen in the 3 phrases while syndrome elements of heat
yin deficiency
dampness
static blood and yang deficiency all had statistical significance in the 3 phrases of the precancerosis of CAG( P < 0. 05). Among them
syndrome element of yin deficiency was common in the phrase of CAG. Syndrome elements of heat and dampness were common in the phrases of CAG and CAG with IM. Syndrome elements of static blood and yang deficiency were common in the phrases of CAG with IN. Conclusion In the process of the precancerosis of CAG
the syndrome and syndrome elements evolution rule of "intermingled deficiency and excess
from deficiency to excess
from excess to deficiency"was present. Qi deficiency of the spleen and stomach is the basic pathogenesis characteristic. Syndrome elements of qi deficiency and qi stagnation can be seen in the whole phrases of the disease. The disease location is in the stomach
related to the liver and spleen.
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