Although traditional Chinese medicine（TCM） and western medicine has own advantages in treating Alzheimer’s disease（AD）

both of them cannot cure it. The combination of the two may be an important way to cure AD. Modern medicine believes that synaptic plasticity is the central event in the disease

combining of the thinking of yin-yang and treatment based on syndrome differentiation of TCM

this paper put forward the three stages of TCM treatment of AD. The early stage is damaging to long-term potentiation（LTP）

and the treatment should warm and tonify yang-qi; the middle stage is damaging to LTP and structural plasticity

and the treatment should nourish yin and regulate yang as well as eliminate phlegm and resolve dampness fluid; the advanced stage is senile plaque and synapsis exitotoxicity

and the treatment should replenish essence and marrow as well as detoxify and remove blood stasis.