Chronomedicine of traditional Chinese medicine（TCM） was founded in the Qin and Han Dynasties

developed in Song

Jin

Yuan Dynasties

and matured in the Ming and Qing Dynasties. This paper combed the relevant content of time rhythm in the Inner Canon of Yellow Emperor（《黄帝内经》）

including the physiological rhythms such as day and night and nutrient qi and defensive qi movement

moon events

pulses

seasonal changes

and pathological rhythms of disease allivated in the morning

quietude in the daytime

deteriorated at the dusk and severe at night

disease onset of five zang-organs according time

pathogen qi hidden in four seasons and then attacked. It is believed that the rhythmic nature in TCM can help to understand the onset time

symptoms and course characteristics of the disease

so as to guide the clinical application of acupuncture. According to the circadian rhythm

the method of reconciling nutrient qi and defensive qi is used to treat insomnia caused by inconsistent nutrient qi and defensive qi; the rhythm of the year and month is used to reconcile qi and blood to treat dysmenorrhea caused by qi and blood irregularities; according to the four seasons law combined with the location of pathogen qi

the depth of acupuncture was adjusted; In respond to those who are ill at the time

according to the nature of the disease

it is the key point to prevent evil from spreading; For diseases caused by hidden pathoen

it should receive early treatment and prevent reoccurrence after recover.