This paper investigates evolution from the theory of five zang-viscera storing spirit in Inner Canon of Yellow Emperor（《黄帝内经》） and the theory of five spirit zang-viscera in Grand Simplicity of Inner Canon of Huangdi（《黄帝内经太素》）. From the perspective of"debate between physique and spirit in the Six Dynasties"

this paper holds that the focus of the debate was whether sprit was qi or not

and the purpose was to prove whether spirit was extinct or immortal. People supporting the theory of spirit could be extinct believed that spirit was from gradual qi evolution that spirit was based on qi

while people supporting the theory of spirit was immortal believed that spirit was not from qi evolution that spirit did not need qi as the material basis. Affected by this

the core of the theory of visceral manifestations in Grand Simplicity of Inner Canon of Huangdi changed from the theory of five zang-viscera storing spirit in the period of Inner Canon of Yellow Emperor to the theory of five spirit zang-viscera. The purpose of five zang-viscera storing essence qi is to store five spirits

and the five kinds of essence qi become the material basis of the spirits instead of "spirit is essence qi"in Inner Canon of Yellow Emperor. During this period

the evolution trends of medical thought and philosophical thought were consistent

and they were all completed under the impact of Buddhism

a foreign thought. Clearly understanding this process provides a new way of thinking for the study on evolution of TCM theories.