Chinese materia medica with aconitine is commonly used in clinical treatment of heart failure（HF）

but it is easy to cause arrhythmia and other toxic and side effects

which limits its clinical application. Abnormal calcium circulation in sarcoplasmic reticulum（SR） of cardiomyocytes is one of the main causes of heart failure. Efficacy of aconitine in improving heart failure and its mechanisms of toxic and side effects are closely related to calcium regulation in cardiomyocytes. Acupuncture can improve the abnormal calcium regulation mechanisms in cardiomyocytes by playing a therapeutic role of regulating and mobilizing endogenous mechanisms in the body

so it can reduce the occurrence of toxic and side effects. Based on the calcium regulation mechanisms in cardiomyocytes

this paper discusses the relationship among the pathological mechanism of heart failure

aconitine

acupuncture efficacy and calcium regulation mechanisms in cardiomyocytes

and explores a new idea on acupuncture combined with aconitine in improving heart failure. It is expected to open up an effective and safe way for the combination of acupuncture and aconitine in the treatment of heart failure.