Objective To explore risk factors of cardiovascular disease in people with different traditional Chinese medicine（TCM） constitutions in Hotan Prefecture

Xinjiang. Methods Stratified sampling method was applied to randomly select 810 subjects aged 35-75 years in Hotan Prefecture from March to December

2018. The Chinese Expert Consensus on Risk Assessment of Cardiovascular Disease in Asymptomatic Adults was adopted for assessment. Asymptomatic subjects were selected for scoring through a scale questionnaire on identification of TCM constitutions and an assessment form on 10-year risk of ischemic cardiovascular disease in Chinese people. The 10-year absolute risk of cardiovascular disease in the subjects was calculated. Body mass index（BMI）

systolic blood pressure

total cholesterol and other data were obtained from the physical examination database system. Distribution of different TCM constitutions in the subjects

and distribution of exposure to different risk factors

absolute risk grouping and TCM constitutions in the subjects were analyzed. Logistic regression analysis was performed for different TCM constitutions and TCM constitutions in subjects with medium to high risk of cardiovascular disease. Results A total of 804 eligible subjects were enrolled in this study

mainly including qi-deficiency constitution（37.2%）

balanced constitution（25.3%）

yang-deficiency constitution（13.7%） and phlegm-dampness constitution（7.21%）. There were statistically significant differences in the distribution of TCM constitutions between abnormal systolic blood pressure subjects and diabetic subjects（P<0.001

P=0.006）

while there were no significant differences in the distribution of TCM constitutions among subjects with smoking history

abnormal total cholesterol and abnormal BMI（P>0.05）. The absolute risk distribution of cardiovascular diseases among TCM constitutions was different

and the difference was statistically significant（P<0.001）. There was a significant correlation between TCM constitutions and medium to high risk of cardiovascular disease（P=0.001）

and OR values of qi-deficiency constitution

yin-deficiency constitution

blood-stasis constitution and blood-deficiency constitution were 6.325

9.950

19.900 and 9.185

respectively. Conclusion The TCM constitutions of residents in Hotan Prefecture

Xinjiang are mainly qi-deficiency constitution

balanced constitution

yang-deficiency constitution and phlegm-dampness constitution. TCM constitutions are related to the risk of cardiovascular disease

among which qi-deficiency constitution

yin-deficiency constitution

blood-stasis constitution and blood-deficiency constitution are more significant.