Objective To explore the potential mechanisms of treatment of henoch-schonlein purpura（HSP） with Xiaoer Zidian Zhenxiao Granules（小儿紫癜疹消颗粒） by the network pharmacology. Methods The chemical composition and action targets of Xiaoer Zidian Zhenxiaoxiao Granules were retrieved by the Chinese Medicine System Pharmacology Analysis Platform（TCMSP） and the Chinese Medicine Molecular Mechanism Bioinformatics Analysis Tool（BATMAN-TCM）

and HSP action targets were collected using Genecard database

and then the action targets of Xiaoer Zidian Zhenxiao Granules were intersected with the targets of HSP by using Venny 2.1. The network map of treatment target of active compounds Xiaoer Zidian Zhenxiao Granules was constructed by Cytoscape 3.2.1

and the protein-protein interaction（PPI） network of the therapeutic targets of Xiaoer Zidian Zhenxiao Granules was constructed by String.The possible mechanisms of the treatment of HSP in children with Xiaoer Zidian Zhenxiao Granules were studied. Results The network map of the active compound treatment targets of Xiaoer Zidian Zhenxiao Granules contained 9 single drugs

206 active compounds and 40 treatment targets. The PPI network contained 39 target proteins

and the key proteins involved interleukin 6（IL-6）

insulin（INS）

and vascular endothelial growth factor A（VEGFA） etc. Enrichment of GO function resulted in 14 items

which involved lipopolysaccharide reactions

hypoxia reactions

and drug reactions. KEGG pathway analysis involved TNF signaling pathway

NF-κB signaling pathway

HIF-1 signaling pathway

and PI3 K-AKT signaling pathway. Conclusion Xiaoer Zidian Zhenxiao Granules are multi-component

multi-target and multi-pathways for the treatment of HSP. TNF signaling pathway

NF-κB signaling pathway and PI3 K-AKT signaling pathway are the main pathways to treat HSP.