Post-marketing safety re-evaluation research usually finds adverse drug reactions（ADR） through passive monitoring

active monitoring

or meta-analysis of the spontaneous reporting system

and re-evaluates was performed based on them. Therefore

post-marketing drug safety research is a systematic and dynamic project. It is difficult to form a drug clinical safety conclusion through a single research paradigm. It is necessary to integrate multiple methods to conduct an objective and comprehensive evaluation. Due to the different data types obtained by various quantitative research methods and qualitative research results

it is difficult to integrate various single results to form a comprehensive result. Mixed methods research（MMR） is a supplement to qualitative research and quantitative research. It can achieve a strong combination of the two research methods. This research model is highly consistent with the characteristics and needs of post-marketing safety reassessment. Therefore

MMR design can be used to integrate quantitative data and qualitative data

and explore ways to build a comprehensive evaluation of the safety of Chinese patent medicines after they are marketed.