Objective To observe the clinical efficacy of Jinhua Qinggan Granule（金花清感颗粒） combined with conventional western medicine in the treatment of mild Coronavirus Disease 2019（COVID-19）. Methods A total of 123 patients with COVID-19 were randomly divided into a treatment group of 82 cases giving Jinhua Qinggan Granule 6 g each time

3 times a day

combined with conventional western medicine treatment and a control group of 41 cases only conventional western medicine treatment. Both groups were treated for 5 day. The disappearance rate of clinical symptoms

hospitalization rate

before and after treatment TCM syndrome scale score

outpatient satisfaction

Hamilton anxiety scale

as well as adverse reaction rate of both groups were observed and compared. Results The symptoms disappearance rate of patients in the treatment group and the control group after treatment was as following: fever 80.3% and 53.1%

fatigue 77.6% and 53.8%

cough 66.1% and 42.9%

expectoration 85.3% and 46.2%)

the difference was statistically significant（P<0.05 or P<0.01）. The hospitalization rate of the treatment group and the control group was 10.98% and 24.39% respectively

and the adverse reaction rate was 32.93% and 0

respectively. After treatment

the scores of TCM Syndrome Scale and Hamilton Anxiety Scale of the treatment group were significantly lower than those of the control group（P<0.05 or P<0.01）. There was no significant difference between groups in the hospitalization rate

symptom disappearance rate of chills

head and body pain

head and body weight

sore throat

sore itching

dry throat

nasal congestion and runny nose

nausea and vomiting and outpatient satisfaction scores（P>0.05）. The adverse reaction rate of the treatment group was higher than that of the control group with significant difference（P<0.01）. Conclusion The treatment of Jinhua Qinggan Granule combined with conventional western medicine treatment can significantly alleviate the clinical symptoms of fever

cough

fatigue and expectoration in the mild patients

and relieve anxiety of the patients.