1. 陕西中医药大学
2. 陕西中医药大学附属医院
纸质出版:2020
移动端阅览
[1]徐佳萌,郑刚,任耀龙,齐婧,杨聪,王艳琴.小陷胸汤合丹参饮加味联合西药治疗痰瘀互结型稳定型心绞痛合并H型高血压40例临床观察[J].中医杂志,2020,61(17):1541-1546.
XU Jiameng, ZHENG Gang, REN Yaolong, et al. Clinical Observation on Modified Xiaoxianxiong Decoction and Danshen Yin(小陷胸汤合丹参饮) in the Treatment of 40 Cases of Stable Angina Pectoris Complicated with H Type Hypertension with Syndrome of Intermin-gled Phlegm and Blood Stasis[J]. Journal of Traditional Chinese Medicine2020, 61(17): 1541-1546.
[1]徐佳萌,郑刚,任耀龙,齐婧,杨聪,王艳琴.小陷胸汤合丹参饮加味联合西药治疗痰瘀互结型稳定型心绞痛合并H型高血压40例临床观察[J].中医杂志,2020,61(17):1541-1546. DOI: 10.13288/j.11-2166/r.2020.17.016.
XU Jiameng, ZHENG Gang, REN Yaolong, et al. Clinical Observation on Modified Xiaoxianxiong Decoction and Danshen Yin(小陷胸汤合丹参饮) in the Treatment of 40 Cases of Stable Angina Pectoris Complicated with H Type Hypertension with Syndrome of Intermin-gled Phlegm and Blood Stasis[J]. Journal of Traditional Chinese Medicine2020, 61(17): 1541-1546. DOI: 10.13288/j.11-2166/r.2020.17.016.
目的观察小陷胸汤合丹参饮加味联合西药治疗痰瘀互结型稳定型心绞痛合并H型高血压的临床疗效。方法将80例患者随机分为对照组和治疗组
每组40例。对照组结合病情采用抗心绞痛及降血压等治疗
治疗组在对照组基础上服用小陷胸汤合丹参饮加味
疗程均为28天。比较两组患者治疗前后中医证候积分、心绞痛发生情况、硝酸甘油使用量及血压、同型半胱氨酸(Hcy)水平
治疗后评价中医证候疗效及心电图疗效。结果两组中医证候疗效比较
治疗组总有效率(90.00%)显著高于对照组(72.50%)(P<0.05);心电图疗效比较
治疗组总有效率(65.00%)显著高于对照组(40.00%)(P<0.05)。治疗第21、28天两组中医证候积分与治疗前比较明显降低(P<0.05)
治疗组第28天与第7天比较明显降低(P<0.05);治疗第21、28天时
治疗组的中医证候积分与对照组同时间比较均明显降低(P<0.05)。两组治疗第14、21、28天收缩压、舒张压与治疗前比较均明显降低(P<0.05)
治疗组第28天与第7天及第14天比较均明显降低(P<0.05)
治疗组第28天与第21天比较差异无统计学意义(P>0.05);治疗组治疗第14、21、28天与对照组同时间比较收缩压及舒张压均明显下降(P<0.05)。治疗后两组心绞痛发作次数减少、持续时间缩短
硝酸甘油使用量明显减少(P<0.05)
且治疗组各指标均明显低于对照组(P<0.05)。治疗后两组患者血Hcy均下降(P<0.05)
且治疗组较对照组下降更明显(P<0.05)。结论小陷胸汤合丹参饮加味联合西药能明显改善痰瘀互结型稳定型心绞痛合并H型高血压患者的临床症状
调节血压水平
缓解心绞痛发作情况
降低血Hcy水平。
Objective To observe the clinical effects of modified Xiaoxianxiong Decoction and Danshen Drink(小陷胸汤合丹参饮) in the treatment of stable angina pectoris(SAP) with H type hypertension with syndrome of intermingled phlegm and blood stasis. Method A total of 80 patients were randomly divided into a control group and a treatment group
with 40 cases in each group. The control group was treated with routine therapy for anti angina and hypotension. The treatment group was treated with modified Xiaoxianxiong Decoction and Danshen Drink on the basis of the control group. The treatment course was 28 days. Scores of traditional Chinese medicine(TCM) syndrome
the occurrence of angina pectoris
the use of nitroglycerin
blood pressure
and level of homocysteine(Hcy) were recorded before and after treatment. After treatment
the efficacy of TCM syndromes and the efficacy of electrocardiogram were evaluated. Results Comparing the efficacy of TCM syndromes between the 2 groups
the total effective rate of the treatment group(90.00%) was higher than that of the control group(72.50%)(P<0.05); the ECG curative effect comparison showed that the total effective rate of the treatment group(65.00%) was higher than that of the control group(40.00%)(P<0.05). The scores of TCM syndromes in btoh groups were significantly reduced on the 21 st and 28 th days of treatment compared with those before treatment(P<0.05)
and the scores of the treatment group on the 28 th were significantly lower than on 7 th days(P<0.05). On the 21 st and 28 th days of treatment
the scores of TCM syndromes in the treatment group were significantly reduced at the same time as compared with the control group(P<0.05). The systolic blood pressure and diastolic blood pressure of both groups were significantly reduced on the 14 th
21 st
and 28 th day of treatment(P<0.05)
and the blood pressure of the treatment group was significantly lower on the 28 th day compared with that on the 7 th day and the 14 th day(P<0.05). There was no statistically significant difference between the blood pressure on 28 th day and on the 21 st day in the treatment group(P>0.05). The systolic blood pressure and diastolic blood pressure of the treatment group on the 14 th
21 st
and 28 th day was significantly decreased compared with that of the control group at the same time(P<0.05). After treatment
the number of episodes of angina pectoris in both groups was reduced
the duration was shortened
and the consumption of nitroglycerin was significantly reduced(P<0.05)
and the indicators in the treatment group were significantly lower than those in the control group(P<0.05). After treatment
the blood Hcy of both groups of patients decreased(P<0.05)
and the decrease in the treatment group was more significant than that of the control group(P<0.05). Conclusion Modified Xiaoxianxiong Decoction and Danshen Drink can significantly improve the clinical symptoms of SAP with H type hypertension
regulate blood pressure level
reduce the occurrence of angina and reduce Hcy level.
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