Objective To summarize the adverse reactions of patients with coronavirus disease 2019（COVID-19） after using Qingfei Paidu Decoction（清肺排毒汤）. Methods A total of 383 patients with COVID-19 who were hospitalized in the Western Hospital Region of Union Hospital

Tongji Medical College

Huazhong University of Science and Technology from February 18 to March 5

2020

were routinely given Arbidol hydrochloride tablets or lopinavir ritonavir tablets as well as Qingfei Paidu Decoction at the same time. Three days were a course of treatment

and a maximum of 3 courses were taken. The adverse reactions during the medication were observed. Patients with elevated serum transaminase were randomly divided into groups A and group B. Patients in group A stopped using Arbidol hydrochloride tablets or lopinavir ritonavir tablets and Qingfei Paidu Decoction. At the same time

patients in group B stopped taking Arbidol Hydrochloride tablets or lopinavir ritonavir tablets but continued to take Qingfei Paidu Decoction. The levels of aspartate aminotransferase（AST） and alanine aminotransferase（ALT） were compared between the 2 groups before treatment

after medication and after drug withdrawal. Results A total of 56 of the 338 patients（16.57%） had increased sweating

of which 2 cases（0.59%） had excessive sweating; 12 cases（3.55%） had elevated serum transaminase; 20 cases（5.92%） had epigastric pain; 16 cases（3.25%） had diarrhea symptoms; other adverse reactions such as nausea and vomiting

palpitations

insomnia

blood pressure and blood sugar changes

skin allergies had a low incidence and mild symptoms

and were relieved after stopping the drug. The 12 patients with elevated serum transaminase were randomized in the range of A and B groups

with 6 cases in each group. Compared with those before medication

AST and ALT in groups A and group B increased significantly after medication（P<0.01）

and the level returned to normal after medication withdrawal（P>0.05）. There was no significant difference between the groups in AST

ALT in group A and B before treatment

after medication and withdraw of medication（P>0.05）. Conclusion Patients with COVID-19 using Qingfei Paidu Decoction have a small amount of excessive sweating

epistomach pain

diarrhea

nausea and vomiting

heart palpitations

insomnia and other adverse reactions

elevated serum transaminase after medication might not be related to Qingfei Paidu Decoction.