Objective To observe the clinical effect and safety of modified Guizhi Decoction（桂枝汤） on cold type urticaria of superficies tightened by wind-cold. Methods A total of 60 cases of patients with cold type urticaria of superficies tightened by wind-cold were randomly divided into a treatment group and a control group

with 30 cases in each group. The treatment group received modified Guizhi Decoction for treatment

one dose per day

while the control group was orally given cetirizine hydrochloride tablets

10 mg each time

once a day. Both groups were treated for 28 days. Before treatment and on the 7 th

14 th

and 28 th day of treatment

patients were scored on the degree of itching

number of wheal

diameter of wheal

duration

and frequency of attacks

and the clinical efficacy was determined. Results The markedly effective rate was 96.67% in the treatment group and 80.00% in the control group

and the difference was not statistically significant（P>0.05）. Compared within group before treatment

the degree of pruritus

the number of wheal

the diameter of wheal

and the duration of both groups were reduced on the 7 th

14 th

and 28 th day of treatment（P<0.05）. Frequency of attacks was reduced on the 7 th

14 th and 28 th day in the treatment group and on the 14 th and 28 th day in the control group（P<0.05）. The degree of pruritus

the number of wheal

the duration of attacks

and the frequency of attacks in the treatment group on the 14 th day were lower than those on the 7 th day（P<0.05）; while the degree of pruritus

diameter of wheal

duration and frequency of attacks on the 14 th day were lower than those on the 7 th day（P<0.05）. On the 28 th day

degree of pruritus

diameter of wheal in the treatment group

frequency of attacks in the control group was lower than those on the 14 th day（P<0.05）. Compared with the control group at the same time

the differences were statistically significant in wheal diameter

duration

attack frequency on the 7 th day

degree of pruritus

the number of wheal

attack frequency on the 14 th day

and itching degree

the number of wheal

wheal diameter

duration

frequency of attack on the 28 th day（P<0.05）. Conclusion Modified Guizhi Decoction is safe and effective for cold type urticaria of tightened by wind-cold and can improve clinical symptoms.