Objective To explore the problems and countermeasures in the recruitment of clinical trial subjects. Methods Based on a multi-center clinical trial of traditional Chinese medicine adjuvant chemotherapy for the treatment of colon cancer

drawing on the idea of implementation research methods

through 2 measures of hospital recruitment and media recruitment

the recruitment process of subjects were observed and recorded

and the reasons that affected the recruitment were analyzed and improvements were proposed. Results From September to November 2019

a total of 246 patients were screened. Among them

23 qualified patients were recruited and screened through the hospitals

and 9 patients were finally enrolled. There were 118

47

and 58 patients were called for consultation in the three-month media recruitment

with 4

6

and 10 patients eligible for recruitment on a monthly basis

and finally 0

0

and 1 were enrolled. It was believed that the factors affecting the recruitment may include strict eligibility criteria

difficulty in determining recruiters

untimely record of the trial screening form

incomplete recruitment information

low frequency of recruitment information

high demand for recruitment and implementation resources

and the bias of patients′ willingness to participate in clinical cognitive trials. Conclusion To improve the recruitment efficacy of clinical trial subjects

the media recruitment should be combined with the recruitment in the hospital; the recruitment information should be detailed and appropriate

and the recruitment conditions should be clearly explained; the actual situation of patients

doctors

and clinical researchers should be integrated to enrich the recruitment channel.