Objective To analyze the status quo of clinical research on Helicobacter pylori（Hp） infection in China based on clinical trial registration data. Methods The clinical studies related to Hp infection registered in the Chinese Clinical Trial Registry was searched from the establishment of the database to July 31

2020

and a summary analysis was conducted. Results A total of 270 studies were retrieved

of which 139 studies met the inclusion criteria

including 87 interventional studies

21 observational studies

7 basic researches

9 diagnostic tests

11 etiology/related factor studies

3 epidemiological studies and 1 preventive study. Conclusion In recent years

the clinical registration research of Hp infection in China has shown a significant increasing trend. The focus of intervention research has gradually shifted to modified quadruple therapy

optimized dual therapy

probiotic therapy

and traditional Chinese medicine（TCM） treatment

which to some extent reflects new trends of Hp infection in clinical research. In the future

it is necessary to further optimize the treatment plan of TCM

do a good job in the top-level design of clinical research

and obtain high-quality evidence-based medical evidence through standardized research

which will help playing the important role of TCM in the treatment of Hp infection.