Objective To explore the effects and possible mechanism of Kangfuxin Liquid（康复新液） on chronic atrophic gastritis（CAG） model rats. Methods A total of 140 SD rats were randomly divided into normal group of 26 rats and a model of 114 rats. The model rats were given N-methyl-N′-nitro-N-nitrosoguanidine（MNNG） intragastrically

and simultaneously loaded with ranitidine

sodium salicylate and high-calorie starch paste as multi-factor intervention to prepare CAG model. The 65 successfully modeled rats including 30 female and 35 male were randomly divided into a model group

a folic acid group

and a Kangfuxin Liquid high-dose

medium-dose

and low dose group

with 13 rats in each group. The Kangfuxin Liquid high

medium

and low dose groups were given concentrations of 0.1

0.05

0.025 g/ml Kangfuxin Liquid respectively by gavage; the folic acid group was given 0.146 mg/ml folic acid solution by gavage; the normal group and the model group were given deionization water. The gavage volume of each group was 10 ml/kg

once a day for 8 weeks. The changes of body weight of the rats in each group were compared

the gastric mucosal histopathology score was performed by HE staining

and the levels of serum pepsinogen Ⅰ（PGⅠ）

pepsinogen Ⅱ（PGⅡ）

motilin（MTL） and gastrin（GAS） were detected. Results The body weight of female rats in each group did not change significantly(（P>0.05）. Compared with the normal group

the body weight of male rats in the model group was significantly reduced（P<0.05）; compared with the model group

the body weight of male rats in the Kangfuxin Liquid high-dose group increased significantly（P<0.05）

the weight change of the Kangfuxin Liquid of low-dose group and folic acid group was not significant（P>0.05）. Compared with the normal group

PGⅠ

PGⅡ

MTL

GAS in the model group were significantly reduced

and the gastric mucosal atrophy score was significantly increased（P<0.05）. Compared with the model group

PGⅠ

PGⅡ

MTL and GAS of the folic acid group and the Kangfuxin Liquid high-dose and medium dose group increased significantly

and gastric mucosal atrophy scores were significantly reduced. PGⅠ/PGⅡof the folic acid group

and MTL and GAS of the Kangfuxin Liquid low-dose group increased significantly（P<0.05）; compared with the folic acid group

GAS of the Kangfuxin Liquid high-dose group

the MTL and GAS of the Kangfuxin Liquid medium and low dose groups were significantly reduced（P<0.05）; compared with the Kangfuxin Liquid high-dose group

MTL in the Kangfuxin Liquid medium-dose group

MTL and GAS in the Kangfuxin Liquid medium-dose and low-dose groups were both significantly lower（P<0.05）; MTL and GAS in the Kangfuxin Liquid medium-dose group were higher than those in the Kangfuxin Liquid low-dose group（P<0.05）. Conclusion Kangfuxin Liquid can significantly reduce the degree of gastric mucosal atrophy in CAG model rats

and its mechanism may be related to the increase of serum PGⅠ

PGⅡ

MTL and GAS secretion levels.