Objective To explore the effects of Qizhi Weitong Granules（气滞胃痛颗粒） on gastric sensitivity and mental state of rats with functional dyspepsia. Methods A total of 32 SD rats were randomly divided into a normal group

a model group

a Qizhi Weitong Granules group

and a mosapride group

with 8 rats in each group. Except for the normal group

rats were given iodoacetamide gavage to prepare functional dyspepsia rat models. After successful modeling

the Qizhi Weitong Granules group was given Qizhi Weitong Granules aqueous solution 1.35 g/（kg·d）

and the mosapride citrate group was given mosapride aqueous solution 1.35 g/（kg·d） respectively. The normal group and the model group were given 0.5 ml/100 g distilled water by gavage

once a day in each group for 14 consecutive days. Electromyography and abdominal wall withdrawal reflex（AWR） scores were used to detect the gastric sensitivity of rats

the forced swimming test and the open field test were used to detect the mental state of the rats

and the brain function NMR was used to detect the functional changes of the rat brain before and after intervention. Results Compared with the normal group

in the model group

when the intragastric balloon pressure was 40

60

80 mmHg

the change rate of myoelectric root-mean-square and AWR score increased

the total distance of exercise in the open field experiment was shortened

and the time of immobilization in the water of forced swimming increased（P<0.05 or P<0.01）

mainly manifested as weakened regional homogeneity（Reho） in hypothalamus

hippocampus

midbrain tegment

and olfactory cortex

and weakened amplitude of low-frequency fluctuation（ALFF） in amygdala

hypothalamus

dorsolateral prefrontal lobe

posterior cerebellar. Compared with the model group

in the Qizhi Weitong Granules group

the myoelectric root-mean-square change rate and AWR score at 40

60

and 80 mmHg were significantly reduced

the total distance of exercise was significantly increased

and the immobilization time in the water was shortened（P<0.05 or P<0.01）. The Reho in amygdala

hippocampus

hypothalamus

anterior cingulate cortex

and precuneus was enhanced

and ALFF in he amygdala

hippocampus

and precuneus Reho in enhanced; there was no statistical difference in the indicators of the mosapride group（P>0.05）

the midbrain tegmental and pons increased

and ALFF in hippocampal increased. Compared with the mosapride group

in the Qizhi Weitong Granules group

the root-mean-square change rate and AWR score of rats at 40

60

80 mmHg were significantly reduced

the total distance of activity was significantly increased

and the immobilization time in the water was obvious shortened（P<0.05 or P<0.01）

Reho in the amygdala

hippocampus

and hypothalamus increased

and ALFF in the amygdala and hypothalamus increased. Conclusion Qizhi Weitong Granules can improve the gastric hypersensitivity and mental state in functional dyspepsia model rats

which is manifested by the structural changes in different brain regions.