Objective To explore the superiority and safety of Ershen Fumai Capsules（二参复脉胶囊） versus Xinbao Pills（心宝丸） for the treatment of senile sinus bradycardia. Methods Totally 120 elderly patients with sinus bradycardia were randomly divided into a treatment group and a control group with 60 patients in each group. Besides the conventional treatment for the primary diseases

Ershen Fumai Capsules（0.5 g each capsule

4 capsules per time） plus Xinbao Pills placebo（5 pills per time） were given in the treatment group

while Ershen Fumai Capsules placebo（4 capsules per time） plus Xinbao Pills（60 mg each pill

5 pills per time） were given in the control group

all medication three times daily

for eight weeks. The 24-hour dynamic electrocardiogram

heart rate variability（HRV）

blood lipids

hemodynamic indicators

as well as safety indicators including blood routine

urine routine

stool routine

liver function

kidney function

and electrolytes were measured before and after treatment. The effects on traditional Chinese medicine（TCM） syndromes and dynamic electrocardiogram were evaluated. Results In the treatment group

the total effective rate by TCM syndromes was 85.0%

and the total effective rate by dynamic electrocardiogram was 88.3%

while those in the control group were 68.3% and 70.0%

respectively（P<0.05）. The fastest heart rate

slowest heart rate

average heart rate

total heart rate

and HRV at different time-domain measurements were significantly improved in both groups after treatment（P<0.05）

with more improvements in treatment group than control group in all above indicators except for the root mean square of differences between adjacent or neighboring NN intervals（P<0.05）. The blood lipid indicators including total cholesterol

triglycerides

high-density lipoprotein cholesterol

low-density lipoprotein cholesterol

as well as the hemodynamic indicators including left ventricular ejection fraction

stroke volume

cardiac output and cardiac index were all improved in both groups after treatment（P<0.05）. There were no significant differences in safety indicators when compared after treatment with before treatment

and the incidence of adverse events was not significantly different between treatment and control group（P>0.05）. Conclusion Ershen Fumai Capsules has better effects than Xinbao Pills in treatmenting senile sinus bradycardia

and both treatments are safe.