Objective To explore the establishment paradigm of high-quality clinical guidelines and standards on aplastic anemia in traditional Chinese medicine（TCM）. Methods A literature searching was conducted for either TCM or western medicine（WM） clinical guidelines on aplastic anemia from January 1 st

1990 to December 31 st

2019. Contents on guideline procedures

methods and recommendations were extracted and compared between TCM guidelines and western medicine guidelines. Results Totally

six WM guidelines and standards were included

containing one diagnosis and treatment standard

three diagnosis and treatment recommendations

and two expert′s consensuses

while there were five TCM guidelines and standards

including two clinical practice guidelines

two diagnosis and treatment protocols

and one conference consensus. TCM guidelines and standards supplemented the diagnosis and treatment of aplastic anemia in WM

promoted the traditional treatments to be used in all stages of disease

and standardized the TCM syndromes. Simultaneously

there were certain problems for further improvement

including the lack of interdisciplinary guideline developing team

low quality of clinical evidence

and insufficient development planning. Conclusion The development of TCM guidelines for aplastic anemia cannot completely follow the international general models

but establish the TCM specific evaluation system is needed

so as to promote the diagnosis and treatment system of aplastic anemia in clinical practice.