Objective To evaluate the effect of Simiao Yongan Decoction（四妙勇安汤） on the serum level of high-sensitivity C-reactive protein（hs-CRP） in carotid atherosclerosis patients with stasis-heat interior constraint pattern. Methods A retrospective study was conducted to collect data on carotid atherosclerosis patients who were admitted to encephalopathy department of Dongzhimen hospital from June to December

2019. Patients having stasis-heat interior constraint pattern and hs-CRP level higher than 2 mg/L were included

and were classified into statins group（12 patients） and non-stains group（18 patients） according to whether stains were used. All patients were treated with herbal decoction or granules

2 times a day

in morning and evening

for 2 weeks. Serum hs-CRP levels

blood pressure

blood lipids

and blood sugar were compared before and after treatment. The traditional Chinese medicine（TCM） syndrome effect and safety were assessed

and were compared between with or without use of statins. Results The serum hs-CRP levels of 30 patients were significantly decreased after treatment

and similar changes were seen in stains group and non-stains group when separately analyzed（P<0.01）

but the differences between group were not statistically significant（P>0.05）. The total effectives rate on TCM syndromes was 93.33%

while that of stains group and non-stains group was 91.67% and 94.44%

respectively

with no significant differences between groups（P>0.05）. After treatment

there were no obvious changes in systolic blood pressure

diastolic blood pressure

fasting blood glucose

blood lipids including total cholesterol

triglycerides

low-density lipoprotein cholesterol

and high-density lipoprotein cholesterol

liver function including alanine aminotransferase and aspartate aminotransferase and renal function including creatinine and urea nitrogen（P>0.05）. During the treatment

two cases of loose stools with increased frequency occurred

and no serious adverse events were seen. Conclusion Simiao Yongan Decoction can effectively reduce the serum hs-CRP level and improve the clinical symptoms when treating carotid atherosclerosis patients of stasis-heat interior constraint pattern

and the effect seems not to be affected by the use of stains.