Objective To explore the effect of Xingbi Gel Nasal Drops（醒鼻凝胶滴鼻剂）（XGND） on allergic rhinitis（AR） and its possible mechanism. Methods Fifty-two rats were randomly divided into normal group

model group

XGND group and budesonide group

with 13 rats in each group. Except for the normal group

rats were sensitized by intraperitoneal injection of ovalbumin（OVA） and stimulated by nasal drops of OVA solution

so as to establish an AR model. Beginning on the second day after the seventh sensitization

rats in XGND group received 50μl XGND in both nostrils

while those in budesonide group received 50μl budesonide

and the normal group and model group received same amount of normal saline

twice daily

for 12 days. Behavior scores（sneeze

nasal itching and runny nose） were assessed after experiment. HE staining was used to observe the pathology of the nasal mucosa and count the eosinophils

and to detect the rats′ nasal mucosa Fyn

signal transducer and activator of transcription 5（STAT5） protein

CD19

CD23 levels

serum transforming growth factor-β1（TGF-β1）

and interleukin 10（IL-10） content. Results Compared to the normal group

the model group had higher behavior scores

eosinophil count

serum TGF-β1

IL-10 level

nasal mucosal Fyn protein expression

CD19

and CD23 levels

as well as lower STAT5 protein expression（P<0.05 or P<0.01）. All above mentioned indicators in XGND group and budesonide group significantly improved when compared to those in the model group（P<0.05 or P<0.01）

and there were no statistical differences between XGND group and budesonide group（P>0.05）. Conclusion XGND may prevent IgE from binding to target cells

reduce Fyn phosphorylation

and reduce the release of inflammatory mediators

thereby improving the clinical symptoms of AR such as sneezing

nasal itching and runny nose.