According to the circadian rhythm of the waxing and waning of yin and yang

as well as the ascending and descending of qi movement in the natural world

treatment should be administered during the most optimal time

and thus separated adjustment method is formulated by using different formulas in the morning and evening. The connotation of the separated adjustment method is to use the two methods simultaneously; and the general principle is to adjust yin and yang separately

which can be subdivided into six categories: separately supplement spleen-kidney

separately adjust Ying-Wei（营卫）

diffuse the upper and supplement the lower

clear metal and supplement fire

unblock yang and contain yin

and mediate middle jiao（焦）. Although different methods have their own focus

all take "ascending and descending of yin and yang" as the key principle

follow the circadian rhythm

supplement deficiency with mild paste and pills

and change the method according to the syndromes

providing ideas for treating intractable diseases.