Objective To explore the core combination drugs of Lianhua Qingwen Capsules（Granules）（LHQW）（连花清瘟胶囊/颗粒） for lower respiratory tract infections（LRTI） in the real world. Methods From the hospital information management system（HIS） database of 18 national tertiary first-class hospitals

clinical data on 5902 LRTI patients who were treated with LHQW were extracted. The descriptive analysis of their demographics was conducted

and the Apriori algorithm was used to build the model. Clementine 12.0 was used to perform the correlation analysis of Chinese and Western medicines and to establish the diagram of combination drugs to obtain the weights. The complex network was built on modularity-based fast agglomeration algorithm（Louvain algorithm） to explore the core therapeutic regimen of LHQW in the treatment of LRTI. Results Among the included patients

2830 were male and 2705 were females with 367 cases unreported; 75.3% were older than 45. In clinical practice

LHQW was often used in combination with anti-infectives

antipyretic analgesic and anti-inflammatory drugs

expectorants and antitussives

bronchial expansion drugs

and gastric mucosal protection drugs. Among the core combination medications for curing patients

LHQW

ambroxol

levofloxacin

Xiyanping Injection（喜炎平注射液）

theophylline

acetylsalicylic acid

Tanreqing Injection（痰热清注射液）

dexamethasone

and Fei Li Ke Capsules（肺力咳胶囊） were often used together. In addition

there were three common medication regimens

which were LHQW plus Shenmai Injection（参麦注射液） and levofloxacin

LHQW plus Danhong Injection（丹红注射液） and theophylline

and LHQW plus pantoprazole and levofloxacin plus acetylsalicylic acid. Compared to the common therapeutic drugs

the core medications newly added drugs for replenishing qi and nourishing yin

promoting blood circulation and removing blood stasis. Conclusion The current complex network shows that the core therapeutic drugs are similar to the commonly used clinical drugs. Shenmai Injection

Danhong Injection

and pantoprazole have separate use characteristics.