Objective To explore the clinical effects of Jinyinghua Oral Liquid（金银花口服液） plus interferon spray in treating hand

foot and mouth disease（HFMD） in children with pathogens invading lung-spleen pattern. Methods Eighty HFMD children with pathogens invading lung-spleen pattern were randomly divided into intervention group and control group with 40 cases in each group. The control group took interferon spray only

two sprays per time

six times daily. The intervention group was administered with interferon spray and Jinyinghua Oral Liquid（for youger than 3 years old: 10 ml

twice daily; for 3-7 years old: 10 ml

three times daily; for older than 7 years old: 20 ml

three times daily）; After seven days′ treatment

the resolution time of rash

oral ulcers

sore throat and fever

the immune function indicators including CD3

+

CD4

+

CD8

+

CD4

+

/CD8

+

and inflammation indicators including interleukin 6（IL-6）

serum amyloid A（SAA） were assessed. Results The total effectiveness rate of the intervention group was 92.5%

which was higher than 70.0% of the control group（P

<

0.01）. The resolution time of oral ulcers

sore throat

fever

and rash of the intervention group were all significantly shorter than those of the control group（P

<

0.05 or P

<

0.01）. The CD3

+

and CD4

+

/CD8

+

levels significantly increased in both groups after treatment

and more increase was seen in the intervention group（P

<

0.05 or P

<

0.01）; there were significantly differences between two groups in the CD3

+

and CD4

+

/CD8

+

levels after treatment（P

<

0.05）. After treatment

the IL-6 and SAA levels of intervention group significantly decreased（P

<

0.05 or P

<

0.01）

and the IL-6 level of control group significantly decreased as well（P

<

0.05）; compared to the control group

the intervention group had much lower IL-6 and SAA levels after treatment（P

<

0.05 or P

<

0.01）. Conclusion Jinyinghua Oral Liquid combined with interferon spray is effective for the treatment of children HFMD with pathogens invading lung-spleen pattern by strengthening the immune function and enhancing the inflammation response.