To explore the effectiveness and safety of Erhuang Quzhi Granules（二黄祛脂颗粒） on liver function and blood lipids in patients with non-alcoholic fatty liver disease（NAFLD）. Methods Totally 110 NAFLD patients were randomized into treatment group and control group

with 55 patients in each group. Comprehensive treatment including diet control

proper exerciese

weight control and vitamin E administration（0.5 g per time

three times daily） was given to patients in both groups. Additionally

self-made Erhuang Quzhi Granules（one dose daily） was given to treatment group

while polyene phosphatidylcholine capsules（228 mg each capsule

two capsules per time

three times daily） were given to control group; patients in both groups took three courses of treatment

as one month of each course. The indicators related to liver function including alanine aminotransferase（ALT）

aspartate aminotransferase（AST）

gamma glutamyl transpeptidase（GGT） and blood lipids including triglycerides（TG）

high-density lipoprotein cholesterol（HDL-C）

and low-density lipoprotein cholesterol（LDL-C） were tested before and after treatment to assess the clinical effects

and the adverse events were recorded. Results In the treatment group

27 cases were cured; 14 cases were markedly effective; 9 cases were effective; and 5 cases were ineffective; the total effective rate was 90.90%. Correspondingly

the results in the control group were 15 cases

12 cases

9 cases

19 cases

and 65.45%. There was significant difference between groups in the clinical effects

with results in favor of treatment group（P<0.05）. The levels of ALT

AST

GGT

TG

TC and LDL-C were significantly reduced

while HDL-C level increased in both groups after treatment when compared to those before treatment（P<0.05）; and more changes were seen in treatment group than in control group（P<0.05）. There were no adverse events in both groups. Conclusion Erhuang Quzhi Granules can improve liver function and regulate blood lipid levels in patients with NAFLD

and is considered to be safe.