This paper explored syndrome differentiation and treatment of tumor-related depression based on the theory that "all qi rushing and constraint is ascribed to the lung" recorded in Inner Canon of Yellow Emperor（《黄帝内经》）. Tumor-related depression can be either disease-induced or drug-induced. Either cancer toxin invasion leading to healthy qi insufficiency

or postoperative weakness

or solid tumors obstructing the qi movement can induce failure of the lung to diffuse and govern descent

resulting in qi stagnation and phlegm coagulation accumulated in the body; the lose of qi and phlegm diffuse and release brings about the disease-related depression; banking up and supplementing lung qi is recommended to consolidate the root

while warming the lung and dissolving rheum

resisting cancer and resolving toxins is performed to reform from the bottom. The intestinal and skin adverse reactions（constipation

rash

etc.） induced by anti-cancer drugs can lead to the dysfunction of lung qi to diffuse and govern descent; hard stool and drug toxins are then accumulated in the body

and qi movement is constraint and cannot be diffused

resulting in the drug-induced depression; it is recommended to diffuse the lung to unblock the bowels and unblock sweat pores

so that the hard stool and drug toxins can be dispelled from the body through intestine and skin.