This paper analyses the dose of herbs in the formulas prescribed by famous doctors. It is found that the prescription should follow the principle of “chief

deputy

assistant and envoy”

and the dose of the chief

deputy

assistant and envoy medicinals should decrease from high to low. High dose of the chief medicinals in relation to the main disease

as well as low dose of assistant and envoy medicinals with clear target are recommended

and such formulas with significant differences between doses of chief medicinals and of assistant and anvoy medicinals follows the high and low dose principle. Equal dose of herbs without differentiating between the chief and deputy

as well as the primary and secondary medicinals

are not advocated; otherwise the effect of the formula will be weakened.