This paper introduces professor ZHANG Boli' s thoughts in diagnosis and treatment by examples. In clinical practice， he adopts an integrated thinking way of traditional Chinese medicine （TCM） and Western medicine （WM） to treat the disease， and emphasizes that both TCM and WM should be valued. He is always interpreting the western medicine test and examination results critically rather than adopting them blindly. He takes patients as the center in the treatment， treats what patients are suffered in combination with disease and syndromes differentiation， and treats the root and branch simultaneously， reflecting the humanistic care of TCM and thereby highlighting its clinical effect. Moreover， he is good at prescribing specific formula in correspondence to specific disease， and his prescriptions are in standard behavior， with clear medicinal actions， and are flexible in modification with syndromes.