湖南中医药大学针灸推拿学院,湖南省长沙市岳麓区学士路300号,410208
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收稿:2021-06-27,
修回:2021-09-01,
纸质出版:2021-12-17
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宋家薇,马逸杰,饶泽华等.隔药饼灸对动脉粥样硬化易损斑块模型兔腹主动脉RhoA/Rock信号通路的影响[J].中医杂志,2021,62(24):2184-2191.
SONG Jiawei,MA Yijie,RAO Zehua,et al.Effect of Herbal Cake-Separated Moxibustion on RhoA/Rock Signaling Pathway in the Abdominal Aorta of Rabbits Model with Atherosclerotic Vulnerable Plaques[J].Journal of Traditional Chinese Medicine,2021,62(24):2184-2191.
宋家薇,马逸杰,饶泽华等.隔药饼灸对动脉粥样硬化易损斑块模型兔腹主动脉RhoA/Rock信号通路的影响[J].中医杂志,2021,62(24):2184-2191. DOI: 10.13288/j.11-2166/r.2021.24.013.
SONG Jiawei,MA Yijie,RAO Zehua,et al.Effect of Herbal Cake-Separated Moxibustion on RhoA/Rock Signaling Pathway in the Abdominal Aorta of Rabbits Model with Atherosclerotic Vulnerable Plaques[J].Journal of Traditional Chinese Medicine,2021,62(24):2184-2191. DOI: 10.13288/j.11-2166/r.2021.24.013.
目的
2
探讨隔药饼灸稳定动脉粥样硬化(AS)易损斑块的可能作用机制。
方法
2
将50只新西兰兔随机分为空白组8只,模型组9只,直接灸组9只,隔药饼灸组7只,阿托伐他汀钙组9只,抑制剂组8只。除空白组外,其余各组通过“高脂饲养喂养+腹主动脉球囊损伤术+基因转染+触发斑块破裂”制作AS易损斑块兔模型。空白组、模型组不予操作;阿托伐他汀钙组给予阿托伐他汀钙片1.96 mg/(kg·d)喂养;抑制剂组予盐酸法舒地尔10 mg/(kg·d)沿耳缘静脉缓慢注射;直接灸组及隔药饼灸组分别直接灸及隔药饼灸,穴选Ⅰ组(“巨阙”及双侧“天枢”“丰隆”)或Ⅱ组(双侧“心俞”“肝俞”“脾俞”),每日一组交替使用,每穴连续灸3壮。各组干预时间均为8周。13周实验结束后采用ELISA法测定血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL),并计算HDL/LDL;HE染色观察腹主动脉斑块组织结构,测量血管内膜厚度、内膜-中膜厚度(IMT);免疫组化法观察腹主动脉Ras同源物基因组成员A(RhoA)、Ras同源物相关卷曲螺旋蛋白激酶(Rock)、Toll样受体4(TLR4)、核因子κB(NF-κB)的抗原活性。
结果
2
与空白组比较,模型组实验兔血清TC、TG、LDL含量显著升高,HDL含量及HDL/LDL值显著降低,腹主动脉血管内膜厚度及IMT显著增加,腹主动脉中RhoA、RocK、TLR4、NF-κB灰度值显著升高(
Ρ
<0.01)。与模型组比较,直接灸组、隔药饼灸组、阿托伐他汀钙组TC、TG、LDL明显降低,HDL含量及HDL/LDL值明显升高,内膜厚度、IMT、RhoA、RocK、TLR4、NF-κB灰度值明显下降(
P
<0.05或
P
<0.01)。与直接灸组比较,隔药饼灸组与阿托伐他汀钙组NF-κB灰度值降低(
Ρ
<0.05)。
结论
2
隔药饼灸可能通过抑制RhoA/RocK信号通路下调TLR4、NF-κB表达,从而保护血管内皮功能、稳定AS易损斑块。
Objective
2
To explore the possible mechanism of herbal cake-separated moxibustion in stabilizing the vulnerable plaque of atherosclerosis (AS).
Methods
2
Fifty New Zealand rabbits were randomly divided into blank group (n=8), model group (n=9), direct moxibustion group (n=9), herbal cake-separated moxibustion group (n=7), atorvastatin group (n=9) and inhibitor group (n=8). The AS vulnerable plaque model was established in all groups except for the blank group by high-fat feeding, balloon injury of abdominal aorta, gene transfection, and trigger plaque rupture. The blank group and model group were not operated. The atorvastatin group was fed with atorvastatin calcium tablets 1.96 mg/(kg·d), and the inhibitor group was injected with fasudil hydrochloride 10 mg/(kg·d) along the ear edge veins. Direct moxibustion group and herbal cake-separated moxibustion group used moxibustion either directly on the acupoints or with a herbal cake; the two acupoints groups, Juque (CV14), bilateral Tianshu (ST25) and Fenglong (ST40) as group 1, or bilateral Xinshu (BL15), Ganshu (BL18) and Pishu (BL20) as group 2, should be used alternatively once daily, three moxa cones for each acupoint; the treatement course of all the groups lasted for 8 weeks. After 13 weeks, the serum total cholesterol (TC), triglycerrdes (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were detected by the ELISA method, and the HDL/LDL was calculated; The pathological changes of vulnerable plaque and the aortic intima thickness, intima-media thickness (IMT) were observed through HE staining; immunohistochemical method was used to observe the antigen activity of Ras homolog gene family, member A (RhoA), Rho-associated coiled-coil kinase (Rock), Toll-like receptor 4 (TLR4), and nuclear factor kappa B (NF-κB) in abdominal aorta.
Results
2
Compared to the blank group, the model group had significantly increased serum content of TC, TG and LDL, decreased HDL and HDL/LDL, increased intima thickness and IMT, as well as the increased grayscale value of RhoA, RocK, TLR4 and NF-κB (
P
<0.01). Compared to the model group, the direct moxibustion group, the herbal cake-separated moxibustion group, and the atorvastatin group had significantly lower level of TC, TG, and LDL, higher HDL and HDL/LDL, and lower aortic intima thickness, IMT, and the grayscale value of RhoA, RocK, TLR4 and NF-κB (
P
<0.05, or
P
<0.01). The grayscale value of NF-κB in the herbal cake-separated moxibustion group and the atorvastatin group were significantly reduced as compared to that in direct moxibustion group (
P
<0.05).
Conclusion
2
Herbal cake-separated moxibustion may downregulate the expression of TLR4 and NF-κB by inhibiting the RhoA/RocK signaling pathway, so as to protect the function of vascular endothelial, and to stabilize AS vulnerable to plaque.
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