Objective

2

To evaluate the effectiveness and safety of

Sanhuang Lishi Formula

（三黄理湿方， SLF） for acute eczema with damp-heat immersion pattern.

Methods

2

Seventy-two acute eczema patients with damp-heat immersion pattern were randomized into intervention group and control group， with 36 patients in each group. All patients were given topical 3% boric acid lotion， and additionally those in the intervention group were administered with oral SLF， one dose daily， while those in the control group were given oral cetirizine tablets， 10mg daily at dinner time； the course of treatment was 2 weeks. The eczema area and severity index （EASI） score， the percent of itching time （PIT） in night sleep， the visual analogue scale （VAS） score of pruritus， traditional Chinese medicine （TCM） symptoms score， peripheral blood interleukin-4 （IL-4）， and eosinophil count （EOS） were evaluated and compared before and after treatment； the 1-month recurrence rate in cured or markedly effective patients were compared between two groups， and the adverse reactions were observed.

Results

2

The EASI score， PIT， VAS score， TCM symptom score， serum IL-4 and EOS in the intervention group significantly decreased after treatment （

P

＜0.05）； the cured and markedly effective rate of the intervention group was 47.2%， and the total effective rate was 80.6%. Compared to those in the control group， the decreases of the EASI score， PIT and TCM symptom score in the intervention group were more significant （

P

＜0.01）； the decrease of EOS was more significant （

P

＜0.05）； and the cured and markedly effective rate was higher （

P

＜0.05）. There were 3 recurrent cases in 17 cured and markedly effective cases in the intervention group， while 5 of 7 reappeared in the control group. There were no obvious adverse reactions in the two groups.

Conclusion

2

Oral SLF has significant effect in the treatment of acute eczema with damp-heat immersion pattern， which can reduce the inflammatory reaction and improve the patient's TCM syndromes.