Considering current social environment and people's living and behavior habits， this paper holds that chronic fatigue syndrome （CFS） patients often have both deficiency and constraint condition. The deficiency of five

zang

（脏）， imbalance of qi and blood， and constraint and obstruction of meridians and collaterals are the key pathogenesis. In clinical practice， it is suggested to put focus on the pathogenesis of deficiency and constraint， and take methods of supplementing deficiency and resolving constraint. The points of conception vessel， the foot

taiyin

（太阴） spleen channel and the foot

yangming

（阳明） stomach channel can be used to boost

qi

and nourish the blood as well as tonify the deficiency of five

zang

. The points of the hand

jueyin

（厥阴） pericardium channel and the foot

jueyin

liver channel， that is

Neiguan

（PC6） and

Taichong

（LR3）， in combination with the luo-connecting points Lieque （LU7）， Waiguan （TE5） and Fenglong （ST40） as appropriate can be used to rectify

qi

and activate blood as well as resolve the constraint of meridians and collaterals. Moreover， attention should also be paid to regulating the mind， and both mind and brain should be adjusted simultaneously to calm the mind. In addition， it is necessary to use point combination considering the whole body symptoms.