Objective

2

To analyze the medications of traditional Chinese medicine （TCM） in the treatment of coronary heart disease （CHD） with binding of phlegm and stasis syndrome in recent 30 years， thereby providing refe-rence for TCM treatment of CHD with binding of phlegm and stasis syndrome.

Methods

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The literature on TCM for CHD with binding of phlegm and stasis syndrome was searched from CNKI， VIP， Wanfang and PubMed from January 1st， 1991 to September 1st， 2021 by computer. The included literature was graded according to the National Guideline Clearinghouse （NGC） grade of evidence. The commonly used traditional prescriptions， self-designed prescriptions and Chinese patent medicines in the randomized controlled trials （GRADE A evidence） were extracted， and the use of single herbs in different grades of evidence was analyzed.

Results

2

A total of 286 papers on medications for CHD with binding of phlegm and stasis syndrome were included， involving 79 （27.62%） traditional prescriptions， 165 （57.69%） self-made prescriptions and 42 （14.69%） Chinese patent medicines， and with 11 276 patients. The number of grade A， B and C literature were 196 （68.53%）， 20 （6.99%）， and 70 （24.48%）， respectively. In grade A literature，

Gualou Xiebai Banxia Decoction

（瓜蒌薤白半夏汤），

Xuefu Zhuyu Decoction

（血府逐瘀汤） and their modifications were the most commonly used traditional prescriptions （27 papers）；

Guanmai Ningtong Formula

（冠脉宁通方） was the mostly used self-designed prescription （5 papers）； and Danlou tablet was the most commonly used Chinese patent medicine （17 papers）. The high frequently used single herbs were Gualou （

Fructus Trichosanthis

， 67.48%）， Danshen （

Radix et Rhizoma Salviae Miltiorrhizae

， 63.29%）， Banxia （

Rhizoma Pinelliae

， 62.24%）， Chuanxiong （

Rhizoma Chuanxiong

， 47.90%）， Xiebai （

Bulbus Allii Macrostemi

， 47.90%）， Gancao （

Radix et Rhizoma Glycyrrhizae

， 40.21%）， Huangqi （

Radix Astragali

， 33.57%）， Chishao （

Radix Paeoniae Rubra

， 30.77%）， Honghua （

Flos Carthami

， 30.77%）， and Yujin （

Radix Curcumae

， 30.07%）. The single herbs with high frequency in grade A literature were Gualou （46.15%）， Banxia （41.61%）， Danshen （41.26%）， Chuanxiong （33.22%）， and Xiebai （30.07%）. In grade B literature， the most commonly used single herbs were Gualou （5.59%）， Banxia （5.59%）， Danshen （5.59%）， Xiebai （5.24%） and Chuanxiong （3.50%）. The high frequent herbs mentioned in grade C literature were Danshen （16.43%）， Gualou （15.73%）， Banxia （15.03%）， Xiebai （12.59%） and Chuanxiong （11.19%）.

Conclusion

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The commonly used herbs in the treatment of CHD with the binding of phlegm and stasis syndrome are Gualou， Danshen， Banxia， Chuanxiong， Xiebai， Gancao， Huangqi， Chishao， Honghua， and Yujin， following the principle of dissolving phlegm and dispelling stasis， and rationally using prescriptions that have the function of clearing heat and resolving toxins， cooling and invigorating blood， broadening chest and dissipating masses.