Objective

2

To summarize the applications， usage and safety of

Xingpi Capsule

（醒脾胶囊） in clinical practice， thereby providing reference for its rational use and post-marketing evaluation.

Methods

2

A cross-sectional survey was conducted， and questionnaires were designed involving the key issues that clinicians paid attention to when using

Xingpi Capsules

， involving treated diseases and symptoms， dosage， medication time， combined medication and adverse reactions. Sixty-two hospitals were sampled from 8 provinces and municipalities where

Xingpi Capsule

have been clinically used， and two physicians were selected in each hospital. Totally， 124 physicians were surveyed. Questionnaires were collected through

Wenjuanxing

software， and quality control personnel were set for data quality verification and tracking.

Results

2

The response rate of total 124 questionnaires was 91.7%， and there were 111 valid questionnaires. Totally， 100 physicians （90.1%） believed that

Xingpi Capsule

was effective （the judgement was based on the clinical experience of physicians）. Most physicians have used

Xingpi Capsule

to treat chronic enteritis （76.6%）， as well as chronic gastritis （64.0%）， irritable bowel Syndrome （56.8%）， insomnia （40.5%）， and gastric ulcer （39.6%）. Traditional Chinese medicine （TCM） and Western medicine physicians treated similar diseases with

Xingpi Capsule

， but were different for treating clinical symptoms， where TCM physicians were more inclined to believe that

Xingpi Capsule

can significantly improve dizziness （

P

= 0.028） and palpitation （

P

= 0.028）. Physicians were more inclined to use

Xingpi Capsule

alone when treating chronic enteritis （

P

= 0.032）， irritable bowel syndrome （

P

= 0.006）， and ulcerative colitis （

P

= 0.042）， and took

Xingpi Capsule

twice daily

only for the treatment of chronic enteritis （

P

= 0.014）. In addition， there was no significant difference in the frequency and dosage of

Xingpi Capsule

recommended by practitioners for the treatment of different diseases and symptoms （

P

＞0.05）. For safety issue， 92.8% of the physicians said that they did not find uncomfortable conditions of the patients after taking

Xingpi Capsule

， while 7.2% of the physicians claimed patients reaction including gastrointestinal tract reactions， pruritus and drug eruption.

Conclusion

2

Xingpi Capsule

is mainly used to treat chronic enteritis， chronic gastritis， irritable bowel syndrome， insomnia， and gastric ulcer， which is similar between different professional physicians.