Objective

2

To investigate the efficacy and safety of external use of

Erbai Ointment

（二白膏） in the treatment of hand keratotic eczema with blood deficiency and wind dryness syndrome.

Methods

2

Ninety-two patients with hand keratotic eczema and blood deficiency and wind dryness syndrome were included and were randomly divided into treatment group （49 cases） and control group （43 cases）. The treatment group was given

Erbai Ointment

for external use， taking one index fingertip ointment on every 2 cm×1 cm body surface area， massage gently for two minutes， and then wiped off after left on for 30 minutes. The control group was given zinc oxide ointment for external use， with the same application method as the treatment group. Patients in both groups were treated twice a day， one time each in the morning and evening， continuously for 28 days. The standardized Jena hand eczema score （JHS） and the visual analog score （VAS） were assessed before treatment， after 14- and 28-day treatment. The efficacy on skin lesion and pruritus were judged after 14- and 28-day treatment. Meanwhile， the adverse reactions of the subjects were recorded.

Results

2

There was no significant statistical difference in JHS scores between groups before treatment （

P

＞0.05）， while the VAS score of pruritus was significantly higher in the treatment group than in the control group （

P

＜0.05）. The JHS score and pruritus VAS score of patients in both groups decreased significantly after 14- and 28-day treatment （

P

＜0.05）， and were decreased more after 28-day treatment than 14-day treatment （

P

＜0.05）. No significant differences were observed in JHS score and pruritus VAS score between groups after 14-day treatment （

P

＞0.05）， while the JHS and VAS scores in the treatment group after 28-day treatment were lower than those in the control group （

P

＜0.05）. The total effective rates on skin lesions after 14- and 28-day treatment were 63.27% and 97.96%， respectively， while those on pruritus were 70.21% and 95.74% in the treatment group. In control group， the 14- and 28-day total effective rates were 46.51% and 83.72% on skin lesions， and were 27.78% and 58.33% on pruritus， respectively （

P

＜0.05 or

P

＜0.01）. There were no obvious adverse reactions during treatment in both groups.

Conclusion

2

Erbai Ointment

and zinc oxide ointment are both effective and safe in the treatment of hand keratotic eczema， and

Erbai Ointment

is superior.