The self-organization system of

zang

-

fu

organs （脏腑） is the internal power of the body's evolution influenced by the seasonality， as well as an important guarantee for the smooth transition of evolution. Seasonal period is critical to the evolution of the system. Once the self-organization system of

zang

-

fu

organs （脏腑） is disrupted， the self-stabilization of the system is broken， and then the pathological phenomenon of the disordered relationship between heaven and humankind occurs due to internal and external causes， all of which explains the main pathogenesis of seasonal diseases. Therefore， it is suggested to consider the pathogenesis of seasonal diseases from the dynamic evolution of the time structure， and put focus not solely on the elimination of specific pathogenic factors， but rather the regulation of the body's self-organization mechanism as the root. Only in this way can it follow the trend of “evolution over time”， restore the self-stabilization and defense mechanism of the five

zang

organs， enhance the self-organization ability of the body， harmonize the relationship between heaven and humankind， thereby taking aim at achieving harmonious state of the body in terms of “evolution over time”.