1.南京中医药大学中医学院·中西医结合学院,江苏省南京市栖霞区仙林大道138号,210023
2.南京中医药大学附属医院/江苏省中医院
shupengsp@njucm.edu.cn
收稿:2022-06-23,
修回:2022-11-20,
纸质出版:2023-04-17
移动端阅览
温芳,黄雯洁,李烨等.益气化瘀解毒方辅助化疗对胃癌Ⅳ期脾胃气虚、瘀毒内阻证患者血清炎症因子及生活质量的影响[J].中医杂志,2023,64(08):812-819.
WEN Fang,HUANG Wenjie,LI Ye,et al.Effect of Yiqi Huayu Jiedu Decoction (益气化瘀解毒方) Combined with Chemotherapy on Serum Inflammatory Factors and Quality of Life in Patients of Stage Ⅳ Gastric Cancer with Spleen-stomach Qi Deficiency and Internal Obstruction of Stasis Toxin Syndrome[J].Journal of Traditional Chinese Medicine,2023,64(08):812-819.
温芳,黄雯洁,李烨等.益气化瘀解毒方辅助化疗对胃癌Ⅳ期脾胃气虚、瘀毒内阻证患者血清炎症因子及生活质量的影响[J].中医杂志,2023,64(08):812-819. DOI: 10.13288/j.11-2166/r.2023.08.011.
WEN Fang,HUANG Wenjie,LI Ye,et al.Effect of Yiqi Huayu Jiedu Decoction (益气化瘀解毒方) Combined with Chemotherapy on Serum Inflammatory Factors and Quality of Life in Patients of Stage Ⅳ Gastric Cancer with Spleen-stomach Qi Deficiency and Internal Obstruction of Stasis Toxin Syndrome[J].Journal of Traditional Chinese Medicine,2023,64(08):812-819. DOI: 10.13288/j.11-2166/r.2023.08.011.
目的
2
观察益气化瘀解毒方辅助化疗治疗胃癌Ⅳ期脾胃气虚、瘀毒内阻证的疗效及安全性,并探讨其作用机制。
方法
2
将70例胃癌Ⅳ期脾胃气虚、瘀毒内阻证患者随机分为治疗组及对照组各35例。对照组患者仅给予常规化疗,21天为1个化疗周期;治疗组患者在化疗基础上给予益气化瘀解毒方口服,每日1剂。两组均治疗2个化疗周期。治疗前后检测血清炎症因子[包括(白细胞介素1β(IL-1β)、白细胞介素2(IL-2)、白细胞介素12p70(IL-12p70)、白细胞介素4(IL-4)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)]水平、肿瘤标志物[包括癌胚抗原(CEA)、糖类抗原199(CA199)]水平,进行中医证候(胃痛、胃胀、纳少、嗳气、泛酸、进食梗阻、呕吐、腹泻、便结、乏力10项症状)评分、Karnofsky功能状态评分(KPS评分);治疗后判定肿瘤客观疗效、中医证候疗效及生活质量疗效,记录两组患者治疗过程中不良事件发生情况判定安全性。治疗后采用Pearson相关性分析评价治疗组患者血清炎症因子、肿瘤标志物水平与KPS评分的相关性。
结果
2
与本组治疗前比较,治疗组治疗后IL-1β、IL-2、IL-12p70、TNF-α及IFN-γ水平均明显升高,IL-4、IL-6、IL-10表达水平均明显降低,除便结外其余各项中医症状评分以及总分均明显降低(
P
<0.05或
P
<0.01)。治疗后两组患者血清CEA、CA199水平均较本组治疗前明显降低(
P
<0.05)。治疗组肿瘤客观疗效客观缓解率为34.29%,与对照组的20.59%比较差异无统计学意义(
P
>0.05)。治疗组中医证候疗效总有效率为65.71%,生活质量疗效改善率为65.71%,均分别高于对照组的26.47%、32.35%(
P
<0.05)。两组患者在白细胞减少、血小板减少、贫血、肝功能异常、肾功能异常发生情况方面差异无统计学意义(
P
>0.05)。相关性分析结果显示,治疗组患者KPS评分与IL-1β、TNF-α和IFN-γ之间呈正相关(相关系数分别为0.78、0.88、0.77),而与IL-12p70、IL-8、IL-10呈负相关(相关系数分别为-0.82、-0.95、-0.88)。
结论
2
益气化瘀解毒方辅助化疗能够明显改善胃癌Ⅳ期脾胃气虚、瘀毒内阻证患者临床症状,提高生活质量,且安全性好,其机制可能与调节失衡的免疫炎性因子、改善免疫微环境有关。
Objective
2
To explore the effect and safety of
Yiqi Huayu Jiedu Decoction
(益气化瘀解毒方, YJD)combined with chemotherapy in the treatment of stage Ⅳ gastric cancer (GC) with spleen-stomach
qi
deficiency and internal obstruction of stasis toxin syndrome, and discuss the possible mechanism.
Methods
2
Seventy patients with stage Ⅳ GC and spleen-stomach
qi
deficiency and internal obstruction of stasis toxin were randomly divided into treatment group and control group, with 35 cases in each group. The control group was given conventional chemotherapy only, and 21 days was a chemotherapy cycle; the treatment group was given oral YJD on the basis of chemotherapy, once a day. Both groups were treated with two cycles of chemotherapy. The levels of serum inflammatory factors including interleukin 1β (IL-1β), interleukin 2 (IL-2), interleukin 12p70 (IL-12p70), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), the levels of tumor markers including carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199), traditional Chinese medicine (TCM) symptom score regarding stomach pain, stomach bloating, anorexia, belching, acid reflux, feeling blocked when eating, vomiting, diarrhea, constipation, and fatigue, as well as Karnofsky performance status scale (KPS) score were detected before and after treatment. The objective efficacy, TCM syndrome effect and quality of life efficacy were judged after treatment, and the adverse events were recorded during treatment for safety evaluation. Pearson correlation analysis was used to analyze the correlation between serum inflammatory factors, tumor markers and KPS scores in gastric cancer patients in the treatment group.
Results
2
After treatment, the levels of IL-1β, IL-2, IL-12p70, TNF-α and IFN-γ in the treatment group significantly increased, while the levels of IL-4, IL-6 and IL-10, as well as the total TCM symptom score and score of symptoms except for constipation significantly decreased (
P
<0.05 or
P
<0.01) in the treatment group.The serum CEA and CA199 levels in both groups significantly decreased (
P
<0.05) after treatment. There was no significant difference in objective response rate (ORR) between the treatment group (34.29%) and the control group (20.59%,
P
>0.05). The total effective rate regarding the improvement of TCM symptom and the quality of life in the treatment group was both 65.71%, significantly higher than those of the control group (26.47% and 32.35% respectively,
P
<0.05). There was no significant difference between groups in terms of leukopenia, thrombocytopenia, anemia, abnormal liver function, and abnormal renal function (
P
>0.05). Correlation analysis showed that in the treatment group the KPS score was positively correlated to IL-1β, TNF-α, and IFN-γ, correlation coefficients being 0.78, 0.88, and 0.77 respectively, while negatively correlated to IL-12p70, IL-8, and IL-10, correlation coefficients being -0.82, -0.95, and -0.88 respectively.
Conclusion
2
YJD in combination with chemotherapy can significantly improve the clinical symptoms and quality of life and is safe in treating stage Ⅳ GC patients with spleen-stomach
qi
deficiency and internal obstruction of stasis toxin. The mechanism may be related to the regulation of imbalanced inflammatory factors and the improvement of the immune microenvironment.
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