Objective

2

To explore the clinical effect of

Yinqiao Shengban Formula

（银翘升板方， YSF） adjuvant therapy for adult primary immune thrombocytopenia （ITP） with wind-heat damaging collaterals syndrome.

Method

2

Seventy-four ITP patients with wind-heat damaging collaterals syndrome were randomly divided into control group and treatment group， with 37 patients in each group. Both groups were treated with 0.8 mg/（kg·d） of oral prednisone tablet， or other hormones at an equivalent dose such as 0.8 mg/（kg·d） of oral methylprednisolone tablets， with reduced dosage as the condition gradually becomes stable； the treatment group additionally received YSF， one dose daily. After treatment of eight weeks， the clinical curative effect and effect regarding traditional Chinese medicine （TCM） symptoms were judged. The platelet count， bleeding score， and key parameters of thromboelastography including reaction time （R）， coagulation time （K）， maximum amplitude （MA） and coagulation index （CI） were compared between the two groups.

Results

2

Four cases in the control group and two cases in the control group dropped out during the study. Finally， 68 cases were included involving 35 cases in the treatment gorup and 33 cases in the control group. The total clinical effective rate and the effect regarding TCM symptoms of the treatment group was 71.43% and 74.29%， respectively， significantly higher than 45.45% and 30.30% of the control group（

P

＜0.05 or

P

＜0.01）. The improvement degree of TCM clinical efficacy and syndrome in the treatment group was much better than that in the control group （

P

＜0.01）.After treatment， the platelet count increased，while the bleeding score significantly decreased in both groups， and more changes were found in treatment group （

P

＜0.05 or

P

＜0.01）. Thromboelastography showed no statistical significant difference in MA， R and K values before and after treatment （

P

＞0.05）； the CI value significantly decreased after treatment in both groups （

P

＜0.05）.

Conclusion

2

On the basis of modern medical treatment， the application of YSF in adjuvant to glucocorticoid has better effect than glucocorticoid alone in the treatment of ITP with wind-heat damaging collaterals， which can improve the platelet count of patients， improve the bleeding and hypocoagulable condition.