1.湖南中医药大学中医学院,湖南省长沙市岳麓区学士路300号,410208
2.湖南中医药大学第一附属医院
yuron@21.cn.com
收稿:2022-11-20,
修回:2023-04-20,
纸质出版:2023-09-02
移动端阅览
黎柳,李鸿,周敏等.基于火下阴承、异病同治探讨张仲景鸡子黄类方在2型糖尿病中的应用[J].中医杂志,2023,64(17):1813-1818.
LI Liu,LI Hong,ZHOU Ming,et al.Application of ZHANG Zhongjing,s Jizihuang (Egg Yolk) Prescriptions in Type 2 Diabetes Mellitus based on the Theory of “Yin Restricts Fire” and “Many Different Diseases can be Treated in the Same Way”[J].Journal of Traditional Chinese Medicine,2023,64(17):1813-1818. DOI: 10.13288/j.11-2166/r.2023.17.015.
黎柳,李鸿,周敏等.基于火下阴承、异病同治探讨张仲景鸡子黄类方在2型糖尿病中的应用[J].中医杂志,2023,64(17):1813-1818. DOI: 10.13288/j.11-2166/r.2023.17.015.
LI Liu,LI Hong,ZHOU Ming,et al.Application of ZHANG Zhongjing,s Jizihuang (Egg Yolk) Prescriptions in Type 2 Diabetes Mellitus based on the Theory of “Yin Restricts Fire” and “Many Different Diseases can be Treated in the Same Way”[J].Journal of Traditional Chinese Medicine,2023,64(17):1813-1818. DOI: 10.13288/j.11-2166/r.2023.17.015. DOI:
2型糖尿病可归属于中医“消渴病”范畴。“火下阴承”源于《黄帝内经》中“君火之下,阴精承之”,而消渴病核心病机及治法与之相契合。张仲景鸡子黄类三方为百合鸡子汤、黄连阿胶汤、排脓散,分散在《伤寒杂病论》不同篇章之中。剖析总结此三方的机理特点,认为符合“火下阴承”的治法特点,契合2型糖尿病之消渴病机。此三方均由鸡子黄不同配伍组成,百合鸡子汤为鸡子黄配伍百合,可治疗2型糖尿病及其合并精神相关疾病;黄连阿胶汤为鸡子黄配伍阿胶、芍药、黄连、黄芩,可治疗2型糖尿病及其合并心肾系统疾病;排脓散为鸡子黄配伍芍药、桔梗、枳实,可用于治疗2型糖尿病并发痈疽。因此,基于“火下阴承”的相关现代研究提出鸡子黄三方在2型糖尿病中的应用,可为临床治疗提供思路。
Type 2 diabetes mellitus (T2DM) can be categorized into “
xiao ke
(消渴)” in traditional Chinese medicine (TCM). The theory of “
yin
restricts fire” originates from
Inner Canon of Yellow Emperor
(《黄帝内经》) which states that “
yin
essence restricts chief fire”, and the crucial pathogenesis and treatment of
xiao ke
coincide with this theory. ZHANG Zhongjing
,
s three prescriptions of
Jizizhuang
(egg yolk) are
Baihe Jizizi Decoction
(百合鸡子汤),
Huanglian Ejiao Decoction
(黄连阿胶汤) and
Painong
Powder
(排脓散), which are scattered in different chapters of
Treatise on Cold Damage and Miscellaneous Diseases
(《伤寒杂病论》). By analyzing and summarizing the mechanism and characteristics of the three prescriptions, it is found that the three prescriptions are in line with the characteristics of “
yin
restricts fire” and the pathogenesis of T2DM. These three prescriptions are composed of
Jizizhuang
and different medicinals.
Baihe Jizizi Decoction
is composed of
Jizizhuang
and Baihe (
Bulbus Lilii
), and can be used to treat T2DM and mental diseases.
Huanglian Ejiao Decoction
is composed of
Jizihuang,
Ejiao (
Colla Corii Asini
), Shaoyao (
Radix Paeoniae Alba seu Rubra
), Huanglian (
Rhizoma Coptidis
) and Huangqin (
Radix Scutellariae
), which could be used to treat T2DM and cardiorenal system diseases.
Painong Powder
is composed of
Jizizhuang, Shaoyao,
Jiegeng (
Radix Platycodonis
) and Zhishi (
Fructus Aurantii Immaturus
), which can be used to treat T2DM and carbuncle. Therefore, based on the theory of “
yin
restricts fire” and “many different diseases can be treated in the same wa”, this paper propose that the three
Jizihuang
prescriptions could be used in T2DM, which could provide ideas for clinical treatment.
中华医学会糖尿病学分会 . 中国2型糖尿病防治指南(2020年版) [J]. 中华糖尿病杂志 , 2021 , 13 ( 4 ): 315 - 409 .
SUN H , SAEEDI P , KARURANGA S , et al . Idf diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 [J]. Diabetes Res Clin Pract , 2022 , 183 : 109119 . doi: 10. 1016/j.diabres.2021.109119 http://dx.doi.org/10.1016/j.diabres.2021.109119 .
朱富华 . 论“亢则害,承乃制”:变态反应病之中医“自亢”学说 [J]. 中医杂志 , 2008 , 49 ( 1 ): 16 - 18 .
仝小林 . 糖络杂病论 [M]. 北京 : 科学出版社 , 2020 : 8 .
喻嵘 . 紧扣糖尿病病机辨病辨证结合诊治 [J]. 中国中西医结合杂志 , 2019 , 39 ( 3 ): 267 - 269 .
SHARIF S , RAZA MT , MUSHTAQ S , et al . Frequency of depression in patients with type 2 diabetes mellitus and its relationship with glycemic control and diabetic microvascular complications [J]. Cureus , 2019 , 11 ( 7 ): e5145 .
LIU X , LI Y , GUAN L , et al . A systematic review and meta-analysis of the prevalence and risk factors of depression in type 2 diabetes patients in China [J]. Front Med (Lausanne) , 2022 , 9 : 759499 . doi: 10.3389/fmed. 2022.759499 http://dx.doi.org/10.3389/fmed.2022.759499 .
YANG W , LIU M , TIAN Y , et al . The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality [J]. Bmc Endocr Disord , 2022 , 22 ( 1 ): 232 .
THUMMASORN S , APICHAI S , CHUPRADIT S , et al . T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients [J]. PLoS One , 2022 , 17 ( 8 ): e273327 .
LIU Z , ZHAO H , LIU J , et al . FKN/NR signaling pathway regulates hippocampal inflammatory responses: the survival of hippocampal neurons in diabetic rats with chronic unpredictable mild stress [J]. Evid Based Complement Alternat Med , 2022 , 2022 : 8980627 . doi: 10.1155/2022/8980627 http://dx.doi.org/10.1155/2022/8980627 .
袁志鹰 , 高川 , 陈乃宏 , 等 . 百合鸡子汤对慢性应激抑郁大鼠学习记忆及海马超微结构的影响 [J]. 时珍国医国药 , 2021 , 32 ( 9 ): 2123 - 2126 .
袁志鹰 , 李哲 , 林美妤 , 等 . 百合鸡子汤通过BDNF/TrkB介导的PI3K/Akt/mTOR信号通路对CUMS大鼠抗抑郁的影响 [J]. 中成药 , 2021 , 43 ( 3 ): 778 - 782 .
李镇江 , 陈明仁 , 王亚军 . 黄连阿胶汤加减治疗阴虚热盛型糖尿病的临床疗效观察 [J]. 内蒙古中医药 , 2019 , 38 ( 7 ): 14 - 15 .
魏鹏路 , 尚菊菊 , 刘红旭 , 等 . 经典名方黄连阿胶汤的历史沿革及现代应用 [J]. 中国实验方剂学杂志 , 2023 , 29 ( 3 ): 34 - 43 .
冯露夷 . 加减黄连阿胶汤对2型糖尿病大鼠模型降糖机制的初探 [D]. 广州 : 广州中医药大学 , 2015 .
周旭升 , 韩尧 , 朱旭斌 , 等 . 黄连阿胶汤治疗阴虚热盛型2型糖尿病疗效及对患者糖代谢指标的影响 [J]. 四川中医 , 2022 , 40 ( 4 ): 114 - 116 .
王淑静 , 谷松 , 孙明祎 , 等 . 基于“心肾不交”论黄连阿胶汤的临床应用 [J]. 陕西中医 , 2021 , 42 ( 1 ): 96 - 98 .
徐坤元 , 姚晨思 , 李敏 . 基于“态靶因果”探讨2型糖尿病用药策略 [J]. 中华中医药杂志 , 2021 , 36 ( 9 ): 5372 - 5376 .
陈潮祖 . 中医治法与方剂 [M]. 北京 : 人民卫生出版社 , 2009 : 641 .
彭燕霞 , 凌黎明 , 苏海华 , 等 . 黄连阿胶汤加减治疗糖尿病合并失眠症的临床疗效 [J]. 兵团医学 , 2021 , 19 ( 4 ): 62 - 63 .
郑夏洁 , 陈叶 . 加减黄连阿胶汤联合耳穴压豆治疗糖尿病合并失眠患者的临床观察 [J]. 广州中医药大学学报 , 2021 , 38 ( 8 ): 1591 - 1596 .
HUANG W Y , DONG H . Coptidis rhizoma-contained traditional formulae for insomnia: a potential to prevent diabetes? [J]. Chin J Integr Med , 2018 , 24 ( 10 ): 785 - 788 .
郅扶旻 , 王岩岩 , 徐洪涛 , 等 . 从“心肾并调”论治糖尿病肾病的思路及方法 [J]. 中医药信息 , 2021 , 38 ( 1 ): 5 - 7 .
BRAUNWALD E . Diabetes, heart failure, and renal dysfunction: the vicious circles [J]. Prog Cardiovasc Dis , 2019 , 62 ( 4 ): 298 - 302 .
王瑞华 , 徐强 , 李艳芬 , 等 . 黄连阿胶汤对阿霉素诱发心力衰竭模型大鼠心功能及心肌细胞Ca 2+ 浓度的影响 [J]. 中医杂志 , 2022 , 63 ( 2 ): 157 - 163 .
杨桂染 , 李淑贞 , 刘娜 . 加味黄连阿胶汤对顺铂所致大鼠肾毒性的影响 [J]. 中国慢性病预防与控制 , 2010 , 18 ( 2 ): 162 - 163 .
PITOCCO D , SPANU T , DI LEO M , et al . Diabetic foot infections: a comprehensive overview [J]. Eur Rev Med Pharmacol Sci , 2019 , 23 ( 2 Suppl ): 26 - 37 .
王东 , 陈宏伟 , 李敬林 . 从消渴并有头疽论治糖尿病合并痈 [J]. 中华中医药学刊 , 2015 , 33 ( 7 ): 1548 - 1550 .
吴俊伟 , 郭叙喜 , 叶仁群 , 等 . 排脓散加减方治疗血脉瘀阻型糖尿病足溃疡的疗效观察 [J]. 广州中医药大学学报 , 2022 , 39 ( 6 ): 1285 - 1290 .
WANG K , GUO J , CHANG X , et al . Painong-san extract alleviates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota, restoring intestinal barrier function and attenuating TLR4/NF-κB signaling cascades [J]. J Pharm Biomed Anal , 2022 , 209 : 114529 . doi: 10.1016/j.jpba.2021.114529 http://dx.doi.org/10.1016/j.jpba.2021.114529 .
ZHANG MM , YIN DK , RUI XL , et al . Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway [J]. Chin J Nat Med , 2021 , 19 ( 12 ): 912 - 920 .
GRELA ER , KNAGA S , WINIARSKA-MIECZAN A , et al . Effects of dietary alfalfa protein concentrate supplementation on performance, egg quality, and fatty acid composition of raw, freeze-dried, and hard-boiled eggs from polbar laying hens [J]. Poult Sci , 2020 , 99 ( 4 ): 2256 - 2265 .
DOS SL , FLEMING I . Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome [J]. Prostaglandins Other Lipid Mediat , 2020 , 148 : 106407 . doi: 10.1016/j.prostaglandins.2019.106407 http://dx.doi.org/10.1016/j.prostaglandins.2019.106407 .
0
浏览量
1
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010102007558号