Objective

2

To study the characteristics of the five tones of Parkinson's disease （PD） patients based on the theory of "five-viscera phonology"， and provide references for the syndrome differentiation and treatment of PD.

Methods

2

A total of 272 cases of PD patients were collected as the PD group， and 240 individuals， including patient family members and hospital staff， were recruited as the control group. The 25-tone analyzer was used to collect the five-tone characteristics of both PD patients and control group participants. The participants were then stratified into three age groups， 41~55， 56~70， and 71~85 years old， and categorized by gender （male and female） for analysis. The frequency and composition ratio of the five tones were analyzed for both groups across the different age ranges and genders. Additionally， the average voice frequency of each participant was calculated to compare differences between groups， stratified by age range and gender.

Results

2

In the 41~55 and 56~70 age groups， male participants in the PD group and the control group exhibited the highest frequency of

Yu

（羽） tone， with the PD group showing a significantly higher composition ratio of

Yu

tone compared to the control group （

P

＜0.05）； for males in the 56~70 age group， the composition ratios of

Shang

（商） and

Zhi

（徵） tone in the PD group were lower than those in the control group （

P

＜0.05）. For males in the 71~85 age group， both the PD group and the control group had the highest frequency of

Yu

tone， but there was no statistically significant difference in the composition ratios of the five tones between groups （

P

＞0.05）. For female participants in the PD group across all age groups，

Yu

tone was the most frequent， whereas for the control group，

Jue

（角） tone was the most frequent in all age groups， and the composition ratio of

Yu

tone in the PD group was significantly higher than that in the control group across all age groups （

P

＜0.05）； in the 56~70 age group， the composition ratio of

Jue

tone was lower in the PD group compared to that in the control group （

P

＜0.05）. Regarding voice frequency， males in the PD group aged 41~55 and 56~70 had higher voice frequency than those in the control group of the same age range， and similarly， females in the PD group aged 56~70 and 71~85 had higher voice frequency than their counterparts in the control group （

P

＜0.05）.

Conclusion

2

PD patients have a voice with a higher frequency and an increased proportion of

Yu

tone in their five-tone distribution. According to the theory of five-viscera phonology， PD patients may have disease mechanism of kidney essence deficiency.