1.河南中医药大学第一附属医院脑病中心,河南省郑州市金水区人民路19号,450099
2.河南中医药大学第一临床医学院
3.中西医防治重大疾病河南省协同创新中心
4.焦作市第二人民医院
5.河南省中医药科学院脑病研究所
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收稿:2024-04-11,
修回:2024-05-12,
纸质出版:2025-01-17
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宋研博,孙永康,李明远等.运用麝香从“痰、火、瘀、虚”论治最小意识状态[J].中医杂志,2025,66(02):188-192.
SONG Yanbo,SUN Yongkang,LI Mingyuan,et al.Treatment of Minimally Conscious State with Musk Based on "Phlegm,Fire,Blood Stasis,and Deficiency"[J].Journal of Traditional Chinese Medicine,2025,66(02):188-192.
宋研博,孙永康,李明远等.运用麝香从“痰、火、瘀、虚”论治最小意识状态[J].中医杂志,2025,66(02):188-192. DOI: 10.13288/j.11-2166/r.2025.02.014.
SONG Yanbo,SUN Yongkang,LI Mingyuan,et al.Treatment of Minimally Conscious State with Musk Based on "Phlegm,Fire,Blood Stasis,and Deficiency"[J].Journal of Traditional Chinese Medicine,2025,66(02):188-192. DOI: 10.13288/j.11-2166/r.2025.02.014.
认为最小意识状态为处于窍闭神匿到窍开神现的边缘状态,但仍属“中风闭证”范畴,病机总属邪气痹阻、窍闭神匿,病理因素为痰、火、瘀三端,风动和水饮可伴随其中,后期多因气血阴阳的耗伤而致虚闭。治疗上以麝香为君,注意配伍及用药缓急;以开窍为法,同时注重祛邪与扶正。痰、火重者以小承气汤开其下窍、以泄热通腑,以麝香配牛黄开其上窍,以醒神导气。痰浊较甚者以白芷暂代麝香,以涤痰汤豁痰开窍,待痰浊渐消再加用麝香。瘀血为主者以通窍活血汤活血通窍,以求血行风自灭,血利则无水患,瘀血除则窍开神现。窍闭体虚者应开窍扶正、标本兼顾,气虚者以补阳还五汤益气扶正,阴虚者以芍药甘草汤合封髓丹养阴柔筋、封固肾中精气,阳虚者以地黄饮子滋阴补阳开窍。
Minimally conscious state (MCS) is at the edge between closed and open consciousness, but it still belongs to the category of "wind-strike block" syndrome. The basic pathogenesis of MCS is the obstruction of pathogenic
qi
, orifices closed and spirit hidden, with pathological factors including phlegm, fire, and blood stasis. Wind movement and water retention may also be present, and often leading to deficiency syndrome due to the exhaustion of
qi
, blood,
yin
, and
yang
at later stages. Treatment chooses Shexiang (
Moschus
) as the chief medicinal, emphasizing combination of medicinals and urgency of medication administration; the key therapeutic method is to open the orifices, with focuses on expelling pathogens and reinforcing healthy
qi
. For patients with severe phlegm or fire, use
Xiaochengqi Decoction
(小承气汤) to open the lower orifices, discharge heat and unblock the bowels, combined with Shexiang (
Moschus
) and Niuhuang (
Bovis Calculus
) to open the upper orifices, awaken the spirit and guide
qi
. For patients with turbid phlegm as the predominant, temporarily replace Shexiang (
Moschus
) with Baizhi (
Angelicae dahuricae radix
), using
Ditan Decoction
(涤痰汤) to eliminate phlegm to open the orifices, when turbid phlegm gradually subsided, Shexiang (
Moschus
) could be added. For patients with blood stasis as the predominant,
Tongqiao Huoxue Decoction
(通窍活血汤) will be u
sed to activate blood and open orifice, if the blood circulates, the endogenous wind will be calmed, the water will be induced, the orifices will open and the consciousness will restore. For patients with closed orifices and body deficiency, the treatment should open the orifices and reinforce healthy
qi
, and consider the root and branch simultaneously;
qi
deficiency syndrome can be addressed with
Buyang Huanwu Decoction
(补阳还五汤) to boost
qi
and reinforce healthy
qi
;
yin
deficiency syndrome can be treated with
Shaoyao Gancao Decoction
(芍药甘草汤) combined with
Fengsui Pill
(封髓丹) to nourish
yin
, soften sinews, and secure kidney essence;
yang
deficiency can be managed by using
Dihuang Yinzi Decoction
(地黄饮子) to enrich
yin
, supplement
yang
, and open the orifices.
GIACINO JT , ASHWAL S , CHILDS N , et al . The minimally conscious state: definition and diagnostic criteria [J]. Neurol , 2002 , 58 ( 3 ): 349 - 353 .
BRUNO MA , VANHAUDENHUYSE A , THIBAUT A , et al . From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness [J]. J Neurol , 2011 , 258 ( 7 ): 1373 - 1384 .
BRUNO MA , MAJERUS S , BOLY M , et al . Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients [J]. J Neurol , 2012 , 259 ( 6 ): 1087 - 1098 .
林元相 , 徐如祥 . 最小意识状态的定义、诊断标准及临床鉴别 [J]. 中华神经医学杂志 , 2005 , 4 ( 2 ): 203 - 205 .
WEIMAR C , ROTH MP , ZILLESSEN G , et al . Complications following acute ischemic stroke [J]. European Neurol , 2002 , 48 ( 3 ): 133 - 140 .
VEMMOS KN , TAKIS CE , GEORGILIS K , et al . The athens stroke registry:results of a five-year hospital-based study [J]. Cerebrovasc Dis , 2000 , 10 ( 2 ): 133 - 141 .
TONG X , KUKLINA EV , GILLESPIE C , et al . Medical complications among hospitalizations for ischemic stroke in the United States from 1998 to 2007 [J]. Stroke , 2010 , 41 ( 5 ): 980 - 986 .
董月青 . 关注最小意识状态 [J]. 武警医学 , 2017 , 28 ( 1 ): 1 - 4 .
LUAUTÉ J , MAUCORT-BOULCH D , TELL L , et al . Long-term outcomes of chronic minimally conscious and vegetative states [J]. Neurol , 2010 , 75 ( 3 ): 246 - 252 .
王岚 , 王翰 , 刘海萍 , 等 . 麝香的研究现状 [J]. 资源开发与市场 , 2016 , 32 ( 1 ): 77 - 81 .
郝吉福 , 程怡 . 麝香的药理学研究概况 [J]. 时珍国医国药 , 2004 , 15 ( 4 ): 248 - 249 .
李瑾翡 , 王宁生 , 陆惠文 , 等 . 麝香酮药代动力学研究 [J]. 中药新药与临床药理 , 2000 , 11 ( 4 ): 208 - 210,255 .
孙永康 , 王新志 . 王新志从“胃”论治脑病学术观点探析 [J]. 中医杂志 , 2020 , 61 ( 24 ): 2140 - 2144 .
孙永康 , 王新志 , 杨海燕 . 王新志教授在脑系疾病中应用腹诊经验 [J]. 时珍国医国药 , 2019 , 30 ( 3 ): 702 - 703 .
GIACINO JT , KALMAR K , WHYTE J . The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility [J]. Arch Phys Med Rehabil , 2004 , 85 ( 12 ): 2020 - 2029 .
SEEL RT , SHERER M , WHYTE J , et al . Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research [J]. Arch Phys Med Rehabil , 2010 , 91 ( 12 ): 1795 - 1813 .
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