To summarise the clinical experience of treating insomnia with the method of resolving depression， regulating the middle， and tranquilising mind. It is believed that the key to the pathogenesis of insomnia lies in

qi

depression， disharmony of

qi

pivot， and disharmony of

qi

and blood， and the core treatment is to resolve depression， regulating the middle， and tranquilising mind. The self-prescribed

Jieyu Anmian Formula

（解郁安眠方） could be used as the basic treatment， then modified according to the performance of the patient and syndromes. For syndrome of liver depression restricting spleen， the treatment should soothe liver and invigorate spleen， resolve depression and regulate the middle； for syndrome of liver depression and phlegm coagulation， the treatment should resolve depression and phlegm， support the earth and free the wood； for syndrome of liver depression transforming into fire， the treatment should soothe liver and clear fire， resolve depression and dysphoria； for syndrome of

qi

stagnation and blood stasis， the treatment should activate blood and regulate the middle， resolve depression and tranquilise mind.