By sorting out the pathogen transmission patterns based on the channels and collaterals system in

The Inner Canon of Yellow Emperor

（《黄帝内经》）， it is believed that factors such as emotions， diet， and exhaustion-fatigue disturb the

qi

of the

zang

-

fu

organs and channels directly， causing pathogens to transmit from channels to collaterals； pathogens from the nature first invade the head and face， mostly enter through

Fengfu （GV16） and transmit along the six channels； cold-dampness from the nature transmits from collaterals to channels， from the exterior to the interior， and spreads along the collaterals， channels， intestines and stomach， five

zang

organs， and membrane-source. This paper also summarized the characteristics of the disease transmission pattern from collaterals to channels in

The Inner Canon of Yellow Emperor

， pointing out that diseases manifest different features when pathogens are located in collaterals， channels， membrane-source， or

zang

-

fu

organs. It emphasized that in disease treatment， attention should be paid to the identification of early lesions in the meridians， and the important role of therapeutic methods such as acupuncture， daoyin （conduction exercise）， moxibustion， massage and pressing， and tangyun （hot compresses with herbal decoctions） in disease prevention should be brought into play.