中国中医科学院广安门医院,北京市西城区北线阁5号,100053
通信作者:doctorjq@126.com
收稿:2025-09-30,
修回:2025-11-19,
纸质出版:2025-12-02
移动端阅览
徐惠,姜泉,夏聪敏等.“体脏合痹”理论视角下系统性红斑狼疮继发妇产科疾病的病机及诊疗思路[J].中医杂志,2025,66(23):2438-2442.
XU Hui,JIANG Quan,XIA Congmin,et al.Pathogenesis and Therapeutic Approaches of Systemic Lupus Erythematosus Secondary Gynecological and Obstetric Diseases Based on the Theory of "Bi (痹) of both Body and Viscera"[J].Journal of Traditional Chinese Medicine,2025,66(23):2438-2442.
徐惠,姜泉,夏聪敏等.“体脏合痹”理论视角下系统性红斑狼疮继发妇产科疾病的病机及诊疗思路[J].中医杂志,2025,66(23):2438-2442. DOI: 10.13288/j.11-2166/r.2025.23.008.
XU Hui,JIANG Quan,XIA Congmin,et al.Pathogenesis and Therapeutic Approaches of Systemic Lupus Erythematosus Secondary Gynecological and Obstetric Diseases Based on the Theory of "Bi (痹) of both Body and Viscera"[J].Journal of Traditional Chinese Medicine,2025,66(23):2438-2442. DOI: 10.13288/j.11-2166/r.2025.23.008.
系统性红斑狼疮(SLE)可继发卵巢储备功能下降、月经异常及不良妊娠结局等妇产科疾病。基于“体脏合痹”理论,提出SLE继发妇产科疾病的核心在于“体痹”与“脏痹”相互传变,共同作用于“女子胞”。生理上,女子胞通过经络、血脉与体、脏构成内外相合的网络;病理上,正虚则体脏失濡,毒瘀则病邪循冲任等经脉内扰胞宫,胞宫之痹亦可外应体表、加重体脏损伤。因此,SLE继发妇产科疾病的病机演变存在“体痹为先-体痹及脏-体脏合痹”的动态轨迹。治疗上,强调以和正调衡为总纲,调脏安体养胞为主导,以体养脏为协同,实现体脏同治,凸显了“体脏合痹”理论在防治SLE继发妇产科疾病中的指导价值。
Systemic lupus erythematosus (SLE) may lead to secondary gynecological and obstetric disorders such as decreased ovarian reserve function, menstrual abnormalities, and adverse pregnancy outcomes. Based on "
bi
(痹) of both body and viscera" theory, this paper proposed that the core mechanism of SLE secondary gynecological and obstetric diseases lies in the mutual transformation between "body
bi
" and "viscera
bi
", which together affect the uterus. Physiologically, uterus forms an internal-external network with the body and viscera through the meridians and blood vessels. Pathologically, when the healthy
qi
is deficient, nourishment of the body and viscera is impaired; when toxins and stasis accumulate, pathogenic factors disturb the uterus through the
chong
(冲) and
ren
(任) meri-dians. The resulting obstruction in the uterus can, in turn, manifest externally and aggravate damage to the body and viscera. Therefore, the pathogenesis of SLE secondary gynecological and obstetric diseases follows a dynamic trajectory of "body
bi
first, body
bi
affecting viscera, and then
bi
of both body and viscera". In t
reatment, the principle of harmonizing and balancing the healthy
qi
is emphasized. The main approach is to regulate the viscera, stabilize the body, and nourish the uterus, with the coordination of nourishing the viscera through the body, thereby achieving simultaneous treatment of both body and viscera. This highlights the guiding significance of the "
bi
of both body and viscera" theory in preventing and treating SLE secondary gynecological and obstetric diseases.
WECKERLE CE , NIEWOLD TB . The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies [J]. Clin Rev Allergy Immunol , 2011 , 40 ( 1 ): 42 - 49 .
中华医学会风湿病学分会 , 国家皮肤与免疫疾病临床医学研究中心 , 中国系统性红斑狼疮协作组 . 2020中国系统性红斑狼疮诊疗指南 [J]. 中华内科杂志 , 2020 , 59 ( 3 ): 172 - 185 .
张瑾 , 俞秋霞 , 尤欣 . 系统性红斑狼疮患者的生殖健康与妊娠期管理 [J]. 现代实用医学 , 2024 , 36 ( 6 ): 701 - 705 .
GIRBASH EF , ABDELWAHAB SM , FAHAMI DS , et al . Preliminary study on anti-Müllerian hormone, antral follicle count, menstruation and lymphocyte subsets in systemic lupus erythematosus patients [J]. Int J Gynaecol Obstet , 2022 , 159 ( 1 ): 129 - 135 .
李欣 , 王香丽 , 张乐 , 等 . 系统性红斑狼疮成年女性患者月经及相关情况变化 [J]. 中国妇幼健康研究 , 2016 , 27 ( 10 ): 1201 - 1203 .
WIND M , FIERRO JJ , BLOEMENKAMP KWM , et al . Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta-analysis [J]. Lancet Rheumatol , 2024 , 6 ( 10 ): e667 - e683 .
姜泉 . “体脏合痹”理论内涵及其在风湿免疫病防治中的应用思路 [J]. 中医杂志 , 2024 , 65 ( 16 ): 1656 - 1661 .
黄羚 , 江媚 . 从肾-天癸-冲任-胞宫生殖轴论补肾活血法改善子宫内膜容受性低下 [J]. 辽宁中医杂志 , 2021 , 48 ( 10 ): 45 - 48 .
BISTER J , FILIPOVIC I , SUN D , et al . Tissue-specific nonheritable influences drive endometrial immune system variation [J]. Sci Immunol , 2024 , 9 ( 94 ): eadj7168 .
VISNYAIOVÁ K , VARGA I , FEITSCHEROVÁ C , et al . Morphology of the immune cells in the wall of the human uterine tube and their possible impact on reproduction-uterine tube as a possible immune privileged organ [J]. Front Cell Dev Biol , 2024 , 12 : 1325565 . doi: 10.3389/fcell.2024.1325565 http://dx.doi.org/10.3389/fcell.2024.1325565 .
SNÄKÄ T , BEKKAR A , DESPONDS C , et al . Sex-biased control of inflammation and metabolism by a mitochondrial nod-like receptor [J]. Front Immunol , 2022 , 13 : 882867 . doi: 10.3389/fimmu.2022.882867 http://dx.doi.org/10.3389/fimmu.2022.882867 .
YUAN X , XU W , YAN Z , et al . Andrographolide exerted anti-inflammatory effects thereby reducing sex hormone synthesis in LPS-induced female rats, but had no effect on hormone production in healthy ones [J]. Front Pharmacol , 2022 , 13 : 980064 . doi: 10.3389/fphar. 2022.980064 http://dx.doi.org/10.3389/fphar.2022.980064 .
刘耀洲 , 卞铮 , 黄纯翠 , 等 . 系统性红斑狼疮免疫球蛋白G的N-糖基化修饰 [J]. 生物化学与生物物理进展 , 2025 , 52 ( 9 ): 2205 - 2216 .
常甜 , 彭秋伟 , 刘子夏 , 等 . 从气血津液探讨风湿免疫病“体脏合痹”的内涵及时空传变规律 [J]. 中医杂志 , 2025 , 66 ( 22 ): 2333 - 2339 .
职琼格 , 廖袁钰 , 李旺 , 等 . 系统性红斑狼疮患者症状群的研究进展 [J]. 护理学杂志 , 2025 , 40 ( 18 ): 110 - 114 .
李剑明 , 姜泉 , 韩曼 , 等 . 姜泉治疗系统性红斑狼疮合并妊娠经验 [J]. 中国中医基础医学杂志 , 2019 , 25 ( 12 ): 1744 - 1745,1772 .
单雪燕 , 刘瑞华 , 郭子琳 , 等 . 基于阴阳毒理论探讨系统性红斑狼疮的预后及治疗 [J]. 中医杂志 , 2023 , 64 ( 18 ): 1926 - 1929 .
何瑞芬 , 杨永秀 , 梁晓磊 . 卵巢储备功能减退动物模型研究进展 [J]. 中国实验动物学报 , 2024 , 32 ( 2 ): 254 - 259 .
刘霞 , 张丽丽 , 赵伟 , 等 . 环磷酰胺对育龄系统性红斑狼疮患者卵巢功能影响的评价 [J]. 中华医学杂志 , 2019 , 99 ( 3 ): 174 - 177 .
SOYLU KO , PINAR N , OZCAN O , et al . Protective effect of alphalipoic acid in methotrexate-induced ovarian oxidative injury and decreased ovarian reserve in rats [J]. Gynecol Endocrinol , 2017 , 33 ( 8 ): 653 - 659 .
王文琼 , 侯玉珂 , 李春 , 等 . 系统性红斑狼疮患者不良妊娠结局的预测因素 [J]. 北京大学学报(医学版) , 2025 , 57 ( 3 ): 599 - 603 .
SHI H , CHEN L , WANG Y , et al . Severity of anemia during pregnancy and adverse maternal and fetal outcomes [J]. JAMA Netw Open , 2022 , 5 ( 2 ): e2147046 .
TAN Y , YANG S , LIU Q , et al . Pregnancy-related complications in systemic lupus erythematosus [J]. J Autoimmun , 2022 , 132 : 102864 . doi: 10.1016/j.jaut.2022.102864 http://dx.doi.org/10.1016/j.jaut.2022.102864 .
ARTIM-ESEN B , ÇENE E , ŞAHINKAYA Y , et al . Auto-immune haemolytic anaemia and thrombocytopaenia in a single-centre cohort of patients with systemic lupus erythematosus from Turkey:clinical associations and effect on disease damage and survival [J]. Lupus , 2019 , 28 ( 12 ): 1480 - 1487 .
DAVIS-PORADA J , KIM MY , GUERRA MM , et al . Low frequency of flares during pregnancy and post-partum in stable lupus patients [J]. Arthritis Res Ther , 2020 , 22 ( 1 ): 52 .
韩曼 , 姜泉 , 曾小峰 , 等 . 基于“体脏合痹”理论探讨风湿免疫病中西医结合诊疗思维框架的构建 [J]. 中医杂志 , 2025 , 66 ( 21 ): 2209 - 2215 .
李延婷 , 付静思 , 姜泉 , 等 . 养生气功八段锦的源流和中医理论探析 [J]. 世界中西医结合杂志 , 2022 , 17 ( 4 ): 831 - 835 .
田新平 , 赵久良 , 李梦涛 , 等 . 《2022中国系统性红斑狼疮患者生殖与妊娠管理指南》解读 [J]. 协和医学杂志 , 2023 , 14 ( 3 ): 504 - 513 .
杨煜辰 , 夏聪敏 , 姚传辉 , 等 . 基于阴阳五行学说探讨体脏合痹理论在风湿免疫病防治中的应用 [J]. 中医杂志 , 2025 , 66 ( 21 ): 2216 - 2220 .
0
浏览量
0
下载量
2
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010102007558号